1707-14-8

Basic information

• Product Name: PHENMETRAZINE HYDROCHLORIDE CII (200 MG)
• Synonyms: PHENMETRAZINE HYDROCHLORIDE CII (200 MG);2-phenyl-3-methyltetrahydro-1,4-oxazinehydrochloride;3-methyl-2-phenylmorpholinehydrochloride;3-methyl-2-phenyl-morpholinhydrochloride;3-methyl-2-phenyltetrahydro-2h-1,4-oxazinehydrochloride;Preludin;Mefolin;MFCD00242655
• CAS NO: 1707-14-8
• Molecular Formula: C₁₁H₁₅NO*ClH
• Molecular Weight: 213.70384
• EINECS: 216-950-6
• Product Categories: Amines;Aromatics;Heterocycles
• Mol File: 1707-14-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 175-177°C
• Boiling Point: 285.2°Cat760mmHg
• Flash Point: 112.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.00284mmHg at 25°C
• Storage Temp.: Controlled Substance, -20°C Freezer
• CAS DataBase Reference: PHENMETRAZINE HYDROCHLORIDE CII (200 MG)(CAS DataBase Reference)
• NIST Chemistry Reference: PHENMETRAZINE HYDROCHLORIDE CII (200 MG)(1707-14-8)
• EPA Substance Registry System: PHENMETRAZINE HYDROCHLORIDE CII (200 MG)(1707-14-8)

Safety Data

• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 1707-14-8(Hazardous Substances Data)

Usage

Description

PHENMETRAZINE HYDROCHLORIDE CII (200 MG) is a centrally acting stimulant drug that is used as an appetite suppressant. It is a white solid and is classified as a controlled substance due to its potential for abuse and dependence. The brand name for this drug is Preludin, which is manufactured by Boehringer Ingelheim.

Uses

Used in Pharmaceutical Industry:
PHENMETRAZINE HYDROCHLORIDE CII (200 MG) is used as an anorexiant for the treatment of obesity. It works by stimulating the central nervous system, which helps to suppress appetite and promote weight loss.
Used in Controlled Substances:
PHENMETRAZINE HYDROCHLORIDE CII (200 MG) is classified as a controlled substance due to its potential for abuse and dependence. It is regulated to ensure that it is used appropriately and to prevent misuse and diversion.

Therapeutic Function

Antiobesity

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human reproductive effects. Human teratogenic effects by ingestion: developmental abnormalities of the respiratory and gastrointestinal systems, and effects on newborn including neonatal measures or effects. When heated to decomposition it emits very toxic fumes of NOx and HCl.

InChI:InChI=1/C11H15NO.ClH/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10;/h2-6,9,11-12H,7-8H2,1H3;1H

Upstream product

• 21784-30-5 phendimetrazine 
• 127634-96-2 3-Methyl-2-phenyl-morpholine-4-carboxylic acid ethyl ester 

Downstream Products

• 66064-00-4 2-methyl-3-(3-methyl-2-phenyl-morpholin-4-yl)-1-phenoxycarbonyloxy-1-phenyl-propane 
• 66064-01-5 1-carbamoyloxy-2-methyl-3-(3-methyl-2-phenyl-morpholin-4-yl)-1-phenyl-propane 
• 132412-71-6 2-methyl-3-(3-methyl-2-phenyl-morpholin-4-yl)-1-phenyl-propan-1-one 
• 66064-06-0 2-methyl-3-(3-methyl-2-phenyl-morpholin-4-yl)-1-phenyl-propan-1-ol 
• 51169-82-5 3-methyl-2-phenyl-morpholine-4-carboxylic acid amide 

Relevant articles and documents

Synthesis, toxicological, and pharmacological assessment of derivatives of 2-aryl-4-(3-arylpropyl)morpholines

The synthesis of nine original morpholine derivatives, i.e.2-aryl-4-(3- arylpropyl)morpholines, is described. The structure of all synthesised derivatives was proved by IR and 1H-NMR, and some of them by 13C-NMR. Acute toxicity studies of the compounds were performed on mice. A comparative pharmacological study of the in vivo effects on the central nervous system was undertaken using the screening tests: hexobarbital induced sleeping time; locomotor activity; and behaviour despair (for antidepressive activity). The most active compound 4-(2-benzoylethyl)-2-phenyl-3-methyl) morpholine 4e was studied for MAO-A and MAO-B inhibition in vitro in rat brain mitochondria preparations.