171228-61-8

Basic information

• Product Name: 3-Pentanol, 2-[(phenylmethoxy)methoxy]-, (2S,3R)-
• CAS NO: 171228-61-8
• Molecular Formula: C13H20O3
• Molecular Weight: 224.3
• Mol File: 171228-61-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Pentanol, 2-[(phenylmethoxy)methoxy]-, (2S,3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pentanol, 2-[(phenylmethoxy)methoxy]-, (2S,3R)-(171228-61-8)
• EPA Substance Registry System: 3-Pentanol, 2-[(phenylmethoxy)methoxy]-, (2S,3R)-(171228-61-8)

Safety Data

• Hazardous Substances Data: 171228-61-8(Hazardous Substances Data)

Upstream product

• 170985-87-2 Methyl (S)-2-benzyloxymethoxypropanoate 
• 3587-60-8 Benzyloxymethyl chloride 
• 925-90-6 ethylmagnesium bromide 
• 63296-56-0 (S)-(benzyloxymethoxy)propanal 

Downstream Products

• 171228-49-2 posaconazote 
• 185961-30-2 2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one 
• 170985-80-5 4-Bromo-benzenesulfonic acid (1R,2S)-2-benzyloxymethoxy-1-ethyl-propyl ester 

Relevant articles and documents

Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5]

As part of a detailed study, the syntheses, biological activities, and pharmacokinetic properties of hydroxylated analogues of the previously described broad spectrum antifungal agents, Sch 51048 (1), Sch 50001 (3), and Sch 50002 (4), are described. Based on an overall superior profile, one of the alcohols, Sch 56592 (2), was selected for clinical studies.