171962-76-8

Basic information

• Product Name: (2R,3S)-3-(Dibenzylamino)-1-chloro-4-phenylbutan-2-ol
• Synonyms: (2R,3S)-3-(Dibenzylamino)-1-chloro-4-phenylbutan-2-ol
• CAS NO: 171962-76-8
• Molecular Weight: 379.93
• Mol File: 171962-76-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3S)-3-(Dibenzylamino)-1-chloro-4-phenylbutan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-3-(Dibenzylamino)-1-chloro-4-phenylbutan-2-ol(171962-76-8)
• EPA Substance Registry System: (2R,3S)-3-(Dibenzylamino)-1-chloro-4-phenylbutan-2-ol(171962-76-8)

Safety Data

• Hazardous Substances Data: 171962-76-8(Hazardous Substances Data)

Upstream product

• 3081-24-1 H-Phe-OEt 
• 171815-91-1 N,N-dibenzyl phenylalanin ethyl ester 
• 100-39-0 benzyl bromide 
• 171815-94-4 (3S)-3-dibenzylamino-1-chloro-2-oxo-4-phenylbutane 

Downstream Products

• 934971-01-4 (2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt 

Relevant articles and documents

Production method of aminochlorohydrin sulfate

Highly pure (2R,3S)-3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane or (2S,3R)-3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane may be conveniently produced in high yield by: (a) reacting compound (1) with lithiumchloromethane to give compound (2) and at least a byproduct; (b) dissolving compound (2) and the byproduct in a polar solvent and adding water to the solution to precipitate compound (2) as crystals; (c) reducing the crystals of compound (2) to give compound (3) and at least its diastereomer as an impurity; (d) adding sulfuric acid thereto to give compound (4) and at least its diastereomer as an impurity; and (e) precipitating compound (4) as crystals from a solution containing acetic acid ester or acetic acid ester.