173168-16-6

Basic information

• Product Name: (E)-3-tert-butyl-2-methoxy-4,4-dimethyl-1-phenylpent-1-en-3-ol
• Synonyms: (E)-3-tert-butyl-2-methoxy-4,4-dimethyl-1-phenylpent-1-en-3-ol
• CAS NO: 173168-16-6
• Molecular Weight: 276.419
• Mol File: 173168-16-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-tert-butyl-2-methoxy-4,4-dimethyl-1-phenylpent-1-en-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-tert-butyl-2-methoxy-4,4-dimethyl-1-phenylpent-1-en-3-ol(173168-16-6)
• EPA Substance Registry System: (E)-3-tert-butyl-2-methoxy-4,4-dimethyl-1-phenylpent-1-en-3-ol(173168-16-6)

Safety Data

• Hazardous Substances Data: 173168-16-6(Hazardous Substances Data)

Upstream product

• 815-24-7 Di-t-butyl ketone 
• 101-48-4 phenylacetaldehyde dimethyl acetal 

Downstream Products

• 41049-36-9 1-hydroxy-1,3-diphenylacetone 

Relevant articles and documents

LICKOR-Promoted 1,2-elimination in 1,1-dimethoxy-2-phenylethane and 1,1-dimethoxy-2-phenylpropane: synthesis of substituted enol ethers and alkynes

Dimethyl acetals of phenylacetaldehyde 1a and 2-phenylpropionaldehyde 1b, upon treatment with 1.25 equiv. of LICKOR reagent, undergo 1,2-elimination (THF at -95 deg C) promoted by metallation at the benzylic site, and afford the corresponding enol ethers in the E-form.When the substrate is treated with excess of the base (2.5 equiv.), further hydrogen-metal exchange takes place at the α-vinyl site of the elimination product, and carbonyl electrophiles can be added to the carbanionic intermediate yielding allyl alcohols.Experimental procedures are given for the conversion of the α-substituted derivatives into carbonyl compounds, according to an inverse polarity approach.Moreover, allyl alcohols synthesized starting from 1a, can be transformed into prop-2-ynyl alcohols by treatment with LICKOR base.