17452-27-6 Usage
Description
3-Pyridyl isothiocyanate (Py NCS) is an isothiocyanate derivative characterized by its yellow liquid appearance and a specific enthalpy of vaporization at its boiling point (505.15K), which is 44.379 kJ/mol. 3-PYRIDYL ISOTHIOCYANATE is known for its chemical reactivity and potential applications in various industries.
Uses
Used in Chemical Synthesis:
3-Pyridyl isothiocyanate is used as a chemical intermediate for the synthesis of various organic compounds. Its reactivity allows it to participate in a range of chemical reactions, making it a valuable component in the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Analytical Chemistry:
In the field of analytical chemistry, 3-Pyridyl isothiocyanate serves as a derivatizing agent. It is used to convert analytes into more easily detectable and quantifiable forms, enhancing the sensitivity and selectivity of analytical methods.
Used in Pharmaceutical Industry:
3-Pyridyl isothiocyanate is utilized as a building block in the development of new pharmaceutical compounds. Its unique structure contributes to the design of drugs with specific therapeutic properties, potentially leading to the discovery of novel treatments for various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Pyridyl isothiocyanate is employed in the synthesis of pesticides and other crop protection agents. Its role in creating effective and targeted compounds helps to improve agricultural productivity and crop protection strategies.
Used in Research and Development:
3-Pyridyl isothiocyanate is also used in research and development settings to explore its potential applications and properties. Scientists and researchers leverage its chemical characteristics to investigate new areas of chemistry and material science, potentially leading to breakthroughs in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 17452-27-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,4,5 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 17452-27:
(7*1)+(6*7)+(5*4)+(4*5)+(3*2)+(2*2)+(1*7)=106
106 % 10 = 6
So 17452-27-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H4N2S/c9-5-8-6-2-1-3-7-4-6/h1-4H
17452-27-6Relevant articles and documents
Synthesis of thiocarbamoyl fluorides and isothiocyanates using amines with CF3SO2Cl
Jiang, Lvqi,Yi, Wenbin,Wei, Jingjing,Liang, Shuaishuai
, p. 12374 - 12381 (2020/11/10)
A practical and efficient method to synthesize thiocarbamyl fluorides and isothiocyanates from amines with trifluoromethanesulfonyl chloride was developed. In the presence of the reducing agent triphenylphosphine and sodium iodide, thiocarbamyl fluorides and isothiocyanates were synthesized from secondary/primary amine in moderate to excellent yields, respectively. A broad scope of substrates and good functional group compatibility were observed.
Triton-B catalyzed one pot multicomponent synthesis of isothiocyanates in non-aqueous medium
Singh, Neha,Khare, Richa
, p. 1636 - 1638 (2019/06/11)
A facile and novel method to synthesize isothiocyanides from cyclic and acyclic amines and carbon disulphide in DMSO with Triton-B as catalyst in non-aqueous medium is being reported. The method is less tedious and offers excellent yields. The structures have been elucidated by 1H NMR, 13C NMR and mass spectroscopy.
Synthesis of thiocarbamoyl fluorides and isothiocyanates using CF3SiMe3 and elemental sulfur or AgSCF3 and KBr with amines
Zhen, Long,Fan, Hui,Wang, Xiaoji,Jiang, Liqin
supporting information, p. 2106 - 2110 (2019/03/26)
Reactions of thiocarbonyl fluoride derived from cheap, readily available, and widely used CF3SiMe3, elemental sulfur, and KF with secondary amines and primary amines at room temperature in THF provided a wide variety of thiocarbamoyl fluorides and isothiocyanates in moderate to excellent yields, respectively. The two reactions show broad substrate scope and good functional group tolerance. Moreover, AgSCF3 reacts with secondary/primary amines under KBr at room temperature, affording quantitative thiocarbamoyl fluorides/isothiocyanates, which feature late-stage application.
