175596-01-7

Basic information

• Product Name: 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER
• Synonyms: 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER
• CAS NO: 175596-01-7
• Molecular Formula: C₉H₆FNO₂
• Molecular Weight: 179.1478432
• Product Categories: Aromatic Esters
• Mol File: 175596-01-7.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER(175596-01-7)
• EPA Substance Registry System: 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER(175596-01-7)

Safety Data

• Hazardous Substances Data: 175596-01-7(Hazardous Substances Data)

Usage

General Description

4-Cyano-2-fluorobenzoic acid methyl ester is a chemical compound with the molecular formula C9H6FNO2. It is often used as an intermediate in the synthesis of pharmaceutical compounds and agrochemicals. 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER has a white crystalline appearance and is soluble in organic solvents. It is important to handle this chemical with caution as it may be harmful if ingested or inhaled, and can cause skin and eye irritation. Its exact role and applications can vary depending on the specific industry, but it is commonly utilized in the field of research and development of new products. Overall, 4-cyano-2-fluorobenzoic acid methyl ester is a versatile compound with significant potential for various industrial applications.

Upstream product

• 164149-28-4 4-cyano-2-fluorobenzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 557-21-1 dicyanozinc 
• 179232-29-2 methyl 4-bromo-2-fluorobenzoate 
• 67-56-1 methanol 
• 1149388-52-2 methyl 5-amino-4-cyano-2-fluorobenzoate 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 557-21-1 zinc(II) cyanide 
• 148893-72-5 4-chloro-2-fluorobenzoic acid methyl ester 
• 135205-66-2 N?cyanosuccinimide 
• 505083-04-5 3-fluoro-4-methoxycarbonylphenylboronic acid 

Downstream Products

• 85070-58-2 methyl 2-fluoro-4-formylbenzoate 
• 1149388-51-1 methyl 4-cyano-2-fluoro-5-nitrobenzoate 
• 918967-55-2 methyl 4-[amino(hydroxyimino)methyl]-2-fluorobenzoate 
• 1191070-13-9 4-(tert-butoxycarbonylaminomethyl)-2-fluorobenzoic acid methyl ester 
• 847730-68-1 methyl 4-aminomethyl-2-fluorobenzoate 
• 219873-06-0 3-fluoro-4-(hydroxymethyl)benzonitrile 
• 1289571-15-8 2-Fluoro-4-{[(imidazole-1-carbonyl)-amino]-methyl}-benzoic acid methyl ester 
• 1283718-57-9 methyl 2-fluoro-4-(hydroxymethyl)benzoate 
• 1141471-66-0 2-fluoro-4-{5-[2-methyl-2’-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoic acid 
• 1141471-95-5 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoic acid 
• 1141472-59-4 2-fluoro-4-{5-[2’-(methoxymethyl)-2-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoic acid 
• 1141472-96-9 N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine 
• 1141472-91-4 N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine 

Relevant articles and documents

Late-stage Pd-catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media

New technology is described that enables late stage ppm Pd-catalyzed cyanations of highly complex molecules, as well as a wide variety of aryl and heteroaryl halides possessing sensitive functional groups. These reactions are efficient in water containing nanomicelles, formed from a commercially available and inexpensive surfactant. The implications for advancing drug synthesis and discovery are apparent.

NOVEL AROMATIC COMPOUND AND USE THEREOF

Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a pharmacologically acceptable salt: [wherein each substituent is as defined in the DESCRIPTION], has low toxicity, shows good pharmacokinetics, has an action to promote bone formation, and is useful for the prophylaxis or To treatment of metabolic bone diseases (osteoporosis, fibrous osteitis (hyperparathyroidism), osteomalacia, Paget's disease that influences the systemic bone metabolism parameter etc.) associated with a decrease in the bone formation ability as compared to the bone resorption capacity.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

1,6-Naphthyridine or 8-azaquinazoline derivatives (I) are new. 1,6-Naphthyridine or 8-azaquinazoline derivatives of formula (I) are new. D : N or CR 4>; R 4> : H, F, CF 3 or 1-4C alkyl; Ar : 5-R 5>-6-R 6>-2-methyl-4-oxo-4H-1-benzopyran-8-yl; 3-R 6>-4-R 8>-1-naphthyl optionally substituted with 1-3 of R 7>; 7-R 6>-8-R 8>-5-quinolinyl optionally substituted with 1-2 of R 7>; or 2-R 9>-3-R 10>-4-R 8>-5-R 6>-phenyl; R 5> : H, F, Cl, CN, NO 2, CF 3 or 1-4C alkyl; R 6> : H or F; R 7> : halo, 1-4C alkyl, CF 3, 1-4C alkoxy or OCF 3; R 8> : CN or NO 2; R 9> : H or halo; optionally fluorinated 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio of di(1-4C alkyl)amino; or phenyl optionally substituted with halo, 1-4C alkyl or CF 3; R 10> : H, halo or 1-4C alkyl; R 1> : optionally fluorinated 1-4C alkyl; R 2> : 1-6C alkyl optionally substituted with 3-7C cycloalkyl or F; or SO 2R 11>; R 11> : 1-6C alkyl, CF 3 or 3-7C cycloalkyl; or phenyl or heteroaryl optionally substituted with 1-2 of halo, CN, 1-4C alkyl, CF 3, 1-4C alkoxy and/or OCF 3; R 3> : H, F, CF 3 or 1-4C alkyl. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : Hypotensive; Cardiant; Hepatotropic; Nephrotropic; Cerebroprotective. MECHANISM OF ACTION : Mineralocorticoid receptor (MR) antagonist. 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2-methyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide had an IC 50 of 35 nM when tested on cells expressing a GAL4-MR chimera.