176721-03-2

Basic information

• Product Name: 1’-Hydroxy N-Trityl Medetomidine
• Synonyms: 1’-Hydroxy N-Trityl Medetomidine;α-(2,3-DiMethylphenyl)-α-Methyl-1-(triphenylMethyl)-1H-iMidazole-4-Methanol;1-(2,3-Dimethylphenyl)-1-(1-trityl-1H-imidazol-5-yl)ethanol;1-(2,3-Dimethylphenyl)-1-(3-trityl-3H-imidazol-4-yl)ethanol;1-(2,3-dimethylphenyl)-1-(1H-imidazol-4-triphenylmethyl)ethanol;1-(2,3-dimethylphenyl)-1-(1-trityl-1H-imidazol-4-yl)ethan-1-ol
• CAS NO: 176721-03-2
• Molecular Formula: C₃₂H₃₀N₂O
• Molecular Weight: 458.5934
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 176721-03-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: 1’-Hydroxy N-Trityl Medetomidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1’-Hydroxy N-Trityl Medetomidine(176721-03-2)
• EPA Substance Registry System: 1’-Hydroxy N-Trityl Medetomidine(176721-03-2)

Safety Data

• Hazardous Substances Data: 176721-03-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 75-16-1 methylmagnesium bromide 
• 176721-02-1 4-<(2,3-dimethylphenyl)carbonyl>-1-(triphenylmethyl)imidazole 
• 576-23-8 2,3-dimethylbromobenzene 
• 176721-01-0 4-<(2,3-dimethylphenyl)hydroxymethyl>-1-(triphenylmethyl)imidazole 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 676-58-4 methylmagnesium chloride 
• 2142-71-4 1-(2,3-dimethyl-phenyl)-ethanone 
• 184579-26-8 (1-trityl-1H-imidazol-4-yl)magnesium bromide 
• 116795-55-2 1-(1-triphenylmethyl-1H-imidazol-4-yl)-1-ethanone 
• 76-83-5 trityl chloride 
• 76074-88-9 methyl 1-(triphenylmethyl)-1H-imidazole-4-carboxylate 

Downstream Products

• 86347-14-0 medetomidine 
• 113775-47-6 dexmedetomidine 
• 176721-04-3 (S)-dexmedetomidine-L-(+)-tartrate 
• 145108-58-3 (-)-(R)-4-(1-[2,3-dimethylphenyl]ethyl)-1H-imidazole hydrochloride 
• 1021949-47-2 1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene 

Relevant articles and documents

Intermediate for preparing medetomidine and its preparation method and use

The invention provides an intermediate for preparing medetomidine. The intermediate is a compound shown in the formula (I). The invention also provides a preparation method of the intermediate, and ause of the intermediate in the preparation of medetomidine. The compound shown in the formula (I) is used for preparation of medetomidine so that the raw material is cheap and easy to obtain, synthesis processes are simple, the reaction cycle is short, the environmental pollution is avoided, operation is simple, the harsh reaction conditions are avoided, the operation and post-treatment are simple, the yield and the product purity are high, the intermediate in each step is a solid and is easy to purify, a production cost is low, and the intermediate is suitable for industrial large-scale production and conforms to the principle of green chemistry.

Method for preparing dexmedetomidine and intermediate thereof

The invention provides a method for preparing dexmedetomidine and an intermediate thereof. Specifically speaking, the method comprises the steps that a compound shown as a formula II (please see the formula in the description) reacts with metal magnesium to prepare a metal magnesium Grignard reagent, and then the metal magnesium Grignard reagent reacts with a compound shown as a formula III (please see the formula in the description). The process has the advantages of being few in step, high in yield, easy to operate, high in product purity and the like and is quite suitable for large-scale industrialized production.

Method for preparing medetomidine and its salts

The invention provides an improved, highly efficient method for preparing Medetomidine, and its salts, in particular its pharmaceutically acceptable salts. The method utilizes the high reactivity of halogenated imidazoles towards transmetalation with Grignard reagents and the subsequent reaction with 2,3-dimethylbenzaldehyde.