178432-28-5

Basic information

• Product Name: Fmoc-L-Tyr(PO(OEt)2)-OH
• Synonyms: Fmoc-L-Tyr(PO(OEt)2)-OH
• CAS NO: 178432-28-5
• Molecular Weight: 539.522
• Mol File: 178432-28-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Fmoc-L-Tyr(PO(OEt)2)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-L-Tyr(PO(OEt)2)-OH(178432-28-5)
• EPA Substance Registry System: Fmoc-L-Tyr(PO(OEt)2)-OH(178432-28-5)

Safety Data

• Hazardous Substances Data: 178432-28-5(Hazardous Substances Data)

Upstream product

• 133852-23-0 tert-butyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoate 
• 122-52-1 triethyl phosphite 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 1228073-12-8 Fmoc-L-Tyr(PO(OEt)2)-OtBu 
• 134150-54-2 C₃₀H₃₅NO₅Si 

Downstream Products

• 147762-53-6 N-(fluorenylmethyloxycarbonyl)tyrosine-O-phosphate 
• 1300726-27-5 Fmoc-Gly-Try(PO(OEt)2)-Lys-OH 

Relevant articles and documents

A gene vaccine carrier, preparation method and application thereof

The invention discloses a gene vaccine vector, and a preparation method and an application thereof; the gene vaccine vector is a supramolecular hydrogel formed through phosphatase catalysis of a small-molecular peptide; the small-molecular peptide has the structural formula represented by the formula (I), wherein when m=1, n=0, 1, 2 or 3; when n=1, m=1, 2 or 3. The gene vaccine vector after being loaded with DNA has the advantages of strong immunogenicity, large load capacity, no obvious toxicity and injectable immunity. The gene vaccine vector is mild in preparation conditions and simple in process.

Orthogonal enzymatic reactions to control supramolecular hydrogelations

Enzyme-responsive hydrogels have great potential in applications of controlled drug release, tissue engineering, etc. In this study, we reported on a supramolecular hydrogel that showed responses to two enzymes, phosphatase which was used to form the hydrogels and esterase which could trigger gel-sol phase transitions. The gelation process and visco-elasticity property of the resulting gel, morphology of the nanostructures in hydrogel, and peptide conformation in the self-assembled nanostructure were characterized by rheology, transmission electron microscope (TEM), and circular dichroism (CD), respectively. Potential application of the enzyme-responsive hydrogel in drug release was also demonstrated in this study. Though only one potential application of drug release was proved in this study, the responsive hydrogel system in this study might have potentials for the applications in fields of cell culture, controlled-drug release, etc. Copyright

A general and convenient synthesis of novel phosphotyrosine mimetics

A simple and general procedure for preparation of various phosphotyrosine mimetics from the corresponding phenolic precursors is described. In situ silylation of phenol acids followed by treatment with Et3N/CBr4/HP(O)(OEt)2 provides diethyl phosphate intermediates (36-96%), which can be cleanly deprotected in quantitative yields upon treatment with BSTFA/TMSI to afford novel phosphotyrosine mimetics.