179526-95-5

Basic information

• Product Name: 2'-BROMO-4-CHLORO-BIPHENYL
• Synonyms: 2'-BROMO-4-CHLORO-BIPHENYL;2-Bromo-4'-chloro-1,1'-biphenyl;2-Bromo-4`-chloro-bipheny;1-bromo-2-(4-chlorophenyl)benzene;2-Bromo-4'-chloro-1'-biphenyl;1,1'-Biphenyl, 2-bromo-4'-chloro-
• CAS NO: 179526-95-5
• Molecular Formula: C₁₂H₈BrCl
• Molecular Weight: 267.54892
• Mol File: 179526-95-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 41 °C
• Boiling Point: 325.5±17.0 °C(Predicted)
• Appearance: /
• Density: 1.463
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2'-BROMO-4-CHLORO-BIPHENYL(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-BROMO-4-CHLORO-BIPHENYL(179526-95-5)
• EPA Substance Registry System: 2'-BROMO-4-CHLORO-BIPHENYL(179526-95-5)

Safety Data

• Hazardous Substances Data: 179526-95-5(Hazardous Substances Data)

Usage

Chemical Properties

off-white solid

Upstream product

• 108-86-1 bromobenzene 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 108-90-7 chlorobenzene 
• 14774-78-8 4-chlorophenyl lithium 
• 583-53-9 2,3-dibromobenzene 
• 10312-71-7 1,6-bis-(4-chlorophenyl)-3,4-diacetyl-1,5-hexazadiene 

Relevant articles and documents

Visible-Light-Promoted, Catalyst-Free Gomberg-Bachmann Reaction: Synthesis of Biaryls

Biaryls were synthesized via a novel visible-light-promoted Gomberg-Bachmann reaction that does not require a photosensitizer or any metal reagents. The formation of an electron donor-acceptor complex between aryl diazonium salts and pyridine allows, under visible-light irradiation, the synthesis of biaryls in moderate-to-high yields.

Three-component coupling based on flash chemistry. Carbolithiation of benzyne with functionalized aryllithiums followed by reactions with electrophiles

A flow microreactor method for three-component coupling of benzyne was developed based on flash chemistry. o-Bromophenyllithium generated from 1-bromo-2-iodobenzene and a functionalized aryllithium generated from the corresponding aryl halide were mixed at -70 °C. In the subsequent reactor o-bromophenyllithium is decomposed to generate benzyne without affecting the functionalized aryllithium at -30 °C, and carbolithiation of benzyne with the aryllithium took place spontaneously. The resulting functionalized biaryllithium was reacted with an electrophile in the subsequent reactor to give the corresponding three-component coupling product. The precise optimization of reaction conditions using the temperature-residence time mapping is responsible for the success of the present transformation. The present method has been successfully applied to the synthesis of boscalid.