179552-73-9

Basic information

• Product Name: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine
• Synonyms: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine;7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine;N-(3-Chloro-4-fluorophenyl)-7-chloro-6-nitro-4-quinazolinaMine;4-(3-Chloro-4-fluoro phenylamino)-7-chloro-6-nitro-quinazoline;7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine(179552-73-9)
• CAS NO: 179552-73-9
• Molecular Formula: C₁₄H₇Cl₂FN₄O₂
• Molecular Weight: 353
• EINECS: -0
• Mol File: 179552-73-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 503.298 °C at 760 mmHg
• Flash Point: 258.186 °C
• Appearance: /
• Density: 1.634
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 5.07±0.70(Predicted)
• CAS DataBase Reference: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine(179552-73-9)
• EPA Substance Registry System: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine(179552-73-9)

Safety Data

• Hazardous Substances Data: 179552-73-9(Hazardous Substances Data)

Usage

Description

7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine is a nitrogen-containing heterocyclic compound characterized by its unique chemical structure featuring a quinazolinone core with various substituents. 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine is known for its diverse applications in the pharmaceutical and agrochemical industries due to its bioactivity and potential therapeutic properties.

Uses

Used in Pharmaceutical Industry:
7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine is used as a key intermediate in the synthesis of various pharmaceuticals for its potential therapeutic properties. The compound's unique structure allows for the development of new drugs targeting specific diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine is used as a building block for the creation of bioactive compounds with pesticidal, herbicidal, or fungicidal properties. Its incorporation into these compounds can enhance their effectiveness in protecting crops and managing pests.
Used in Synthetic Drugs:
7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine is also utilized in the synthesis of synthetic drugs, where its heterocyclic structure can be modified to create novel compounds with specific pharmacological activities. This allows for the development of new treatments for various medical conditions.
Used in Bioactive Natural Products:
The compound serves as a structural component in the development of bioactive natural products, which are derived from natural sources but may have enhanced or modified properties. This can lead to the discovery of new therapeutic agents with improved efficacy and reduced side effects.
Overall, 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine is a versatile and valuable compound in the fields of pharmaceuticals, agrochemicals, and the development of synthetic drugs and bioactive natural products. Its diverse applications highlight the importance of nitrogen-containing heterocyclic compounds in modern chemistry and their potential to address various challenges in healthcare and agriculture.

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 53449-14-2 7-chloro-6-nitro-4(3H)-quinazolinone 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 31374-18-2 7-chloro-3,4-dihydroquinazolin-4-one 
• 162012-71-7 4,7-dichloro-6-nitro-quinazoline 
• 53449-15-3 7-chloro-8-nitro-3H-quinazolin-4-one 
• 179552-72-8 4-(3-chloro-4-fluoroanilino)-6-isothiocyanato-7-methoxyquinazoline hydrochloride salt 

Downstream Products

• 945553-94-6 N-((3-chloro-4-fluorophenyl)-6-nitro-7-phenylsulfonyl)quinazolin-4-one 
• 314771-88-5 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 
• 314771-76-1 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 

Relevant articles and documents

Benzo nitrogen hetero-aromatic ring compound, and preparation method and applications thereof

The invention belongs to the field of chemical medicine, and discloses a benzo nitrogen hetero-aromatic ring compound represented by formula I, or pharmaceutically acceptable salts, stereisomers, racemic compounds, prodrugs, or solvates thereof. The invention also discloses applications of the benzo nitrogen hetero-aromatic ring compound in preparation of drugs used for treating diseases caused byprotein kinase and/or nicotinamide phosphoribosyltransferase abnormal activity. The benzo nitrogen hetero-aromatic ring compound represented by formula I or the salts thereof possess tyrosine kinaseand Nampt double inhibition effects, can be taken as effective components in treatment or prevention of tumor, are excellent in curative effect, and low in toxic or side effect.

Novel compound having tumor diagnosis or tumor growth inhibitory activity on EGFR mutant and medical uses comprising the same

The present invention relates to a novel compound having activities of diagnosing a tumor having an epidermal growth factor receptor (EGFR) mutant and inhibiting tumor growth, a salt thereof, a contrast medium comprising the same, and a pharmaceutical composition for treating or preventing EGFR-related cancer diseases comprising the same as an active ingredient. The novel compound or the salt thereof according to the present invention does not inhibit a wild type EGFR but selectively inhibits an EGFR variant, and thus can treat and prevent EGFR-related cancer diseases, including lung cancer, colon cancer or breast cancer. Particularly, the compound or the salt thereof according to the present invention can effectively treat and prevent non-small cell lung cancer upon which Iressa or Tarceva cannot have any significant effect. In addition, the compound or the salt thereof according to the present invention responses with a target of Gefitinib-sensitive cancer cells or cancer cells showing EGFR T790M mutation rather than wild type EGFR over-expressed cancer cells, and thus can be used advisably as a contrast medium capable of clearly differentiating EGFR-related cancer cells by imaging.COPYRIGHT KIPO 2017

Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor

A novel series of anilinoquinazoline compounds with C-6 urea-linked side chains was designed and synthesized as reversible inhibitors of epidermal growth factor receptor (EGFR) based on the structure-activity relationships (SARs) of anilinoquinazoline inhibitors. All compounds demonstrated good inhibition of EGFR wild type (EGFR wt) (IC50 = 0.024-1.715 μM) and inhibited proliferation of A431cell line (IC50 = 0.116-22.008 μM). The binding mode of compounds 8a, 8d, 8k and 8o was consistent with the biological results. Moreover, compounds 8k and 8l almost completely blocked the phosphorylation of EGFR in A431 cell line at 0.01 μM. Interestingly, all of the compounds also demonstrated moderate inhibition of EGFR/T790M/L858R (IC 50 = 0.049-5.578 μM). In addition, compounds 8f and 8h blocked the autophosphorylation of EGFR in NCI-H1975 cells at high concentration (10 μM), and compound 8f was confirmed to be an irreversible inhibitor through the dilution method. Importantly, the compounds with C-6 urea-linked side chains which did not contain Michael acceptors demonstrated moderate to strong irreversible EGFR inhibition.