1798-82-9

Basic information

• Product Name: 4-CYCLOPROPYL-BENZOIC ACID
• Synonyms: 4-CYCLOPROPYL-BENZOIC ACID;AKOS BAR-1173;Benzoic acid, 4-cyclopropyl-
• CAS NO: 1798-82-9
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.19
• Mol File: 1798-82-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 221-224°C
• Boiling Point: 305.8°Cat760mmHg
• Flash Point: 139.9°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 0.00035mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.41±0.10(Predicted)
• CAS DataBase Reference: 4-CYCLOPROPYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYCLOPROPYL-BENZOIC ACID(1798-82-9)
• EPA Substance Registry System: 4-CYCLOPROPYL-BENZOIC ACID(1798-82-9)

Safety Data

• Hazardous Substances Data: 1798-82-9(Hazardous Substances Data)

Usage

Description

4-Cyclopropylbenzoic acid, a chemical compound with the molecular structure featuring a cyclopropane ring fused to a benzene ring and a carboxylic acid functional group, is an organic compound with potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
4-Cyclopropylbenzoic acid is used as a key intermediate in the synthesis of Bruton's Tyrosine Kinase (BTK) inhibitors for the treatment of various B-cell malignancies, including chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), and autoimmune diseases. Its unique structure contributes to the development of potent and selective BTK inhibitors, which play a crucial role in modulating the immune system and combating these diseases.

InChI:InChI=1/C10H10O2/c11-10(12)9-5-3-8(4-6-9)7-1-2-7/h3-7H,1-2H2,(H,11,12)

Upstream product

• 500-05-0 2H-pyran-2-one-5-carboxylic acid 
• 6746-94-7 Cyclopropylacetylene 
• 1128-70-7 3-(4-bromo-phenyl)-4,5-dihydro-1H-pyrazole 
• 873-49-4 cyclopropylbenzene 
• 19824-39-6 p-Cyclopropyl-styrol 
• 124-38-9 carbon dioxide 
• 6921-43-3 1-cyclopropyl-4-methyl-benzene 
• 20034-50-8 4-cyclopropylbenzaldehyde 
• 1124-14-7 1-bromo-4-cyclopropylbenzene 
• 544-92-3 copper(I) cyanide 
• 6921-45-5 1-(4-cyclopropylphenyl)ethanone 
• 75-36-5 acetyl chloride 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 3158-71-2 4-cyclopropylaniline 

Downstream Products

• 1202053-87-9 N-(5-(1H-pyrazol-4-yl)thiazolo[5,4-b]pyridin-2-yl)-4-cyclopropylbenzamide 
• 1126-27-8 1-cyclopropyl-4-benzonitrile 
• 76274-94-7 4-cyclopropylbenzenecarboxylic acid chloride 
• 1129-08-4 4-Cyclopropyl-benzoesaeure-amid 
• 1198088-28-6 4-(2-guanidinothiazol-4-yl)phenyl 4-cyclopropylbenzoate hydrobromide 
• 1198088-27-5 4-(2-bromoacetyl)phenyl 4-cyclopropylbenzoate 
• 1198088-26-4 4-acetylphenyl 4-cyclopropylbenzoate 

Relevant articles and documents

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INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and S1P3 receptor subtypes. Analogue 26 (S1P1 IC50 = 0.6 nM) has an excellent pharmacokinetics profile in the rat and dog and is efficacious in a rat skin transplant model, indicating that S1P3 receptor agonism is not a component of immunosuppressive efficacy.