18042-44-9

Basic information

• Product Name: 4-trimethylsilylpropiophenone
• Synonyms: 4-trimethylsilylpropiophenone
• CAS NO: 18042-44-9
• Molecular Weight: 206.36
• Mol File: 18042-44-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-trimethylsilylpropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-trimethylsilylpropiophenone(18042-44-9)
• EPA Substance Registry System: 4-trimethylsilylpropiophenone(18042-44-9)

Safety Data

• Hazardous Substances Data: 18042-44-9(Hazardous Substances Data)

Upstream product

• 123-62-6 propionic acid anhydride 
• 17878-43-2 [4-(trimethylsilyl)phenyl]magnesium bromide 
• 75-77-4 chloro-trimethyl-silane 
• 56255-86-8 2-(4-Bromo-phenyl)-2-ethyl-[1,3]dioxolane 
• 88-15-3 2-Acetylthiophene 
• 93-55-0 1-phenyl-propan-1-one 
• 79-03-8 propionyl chloride 
• 107134-72-5 [4-(dichloroboryl)phenyl]trimethylsilane 
• 13183-70-5 1,4-bis-(trimethylsilyl)benzene 

Downstream Products

• 1009-43-4 4-(trimethylsilyl)styrene 

Relevant articles and documents

Mg-promoted reductive coupling of aromatic carbonyl compounds with trimethylsilyl chloride and bis(chlorodimethylsilyl) compounds

Mg-promoted reductive coupling of aromatic carbonyl compounds (1) with chlorosilanes, such as trimethylsilyl chloride (TMSCl:2), 1,2- bis(chlorodimethylsilyl)ethane (3) and 1,5-dichlorohexamethyltrisiloxane (4), in N,N-dimethylformamide (DMF) at room temperature brought about selective and facile reductive formation of both of carbon-silicon and oxygen-silicon bonds to give the corresponding α-trimethylsilylalkyl trimethylsilyl ethers (5) and cyclic siloxanes (6), (7) in moderate to good yields, respectively. The present facile and selective coupling may be initiated through electron transfer from Mg metal to aromatic carbonyl compounds (1).

One-pot chemoselective functionalization of arylsilanes via cascade metal-metal exchange reactions

A cascade-transmetallation sequence allows a one-pot conversion of arylsilanes into functionalized arylcoppers; they react with various types of electrophiles (allylic halides, acid chlorides, bromoalkynes); bimetallic zinc-copper-reagents can be prepared by this method either directly or in a sequential fashion.