181622-63-9Relevant articles and documents
Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. II. Synthesis and antitumor activity of N5-substituted glutamine analogs
Itoh, Fumio,Yoshioka, Yoshio,Yukishige, Koichi,Yoshida, Sei,Wajima, Megumi,Ootsu, Koichiro,Akimoto, Hiroshi
, p. 1498 - 1509 (2007/10/03)
The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3- d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid (1b, TNP-351) and related compounds was replaced with some N5-substituted glutamines. Antifolates (4A-S) were effectively prepared