1836-74-4

Basic information

• Product Name: 1-(4-Chlorophenoxy)-4-nitrobenzene
• Synonyms: 1-chloro-4-(4-nitrophenoxy)benzene;4’-chloro-4-nitrobiphenylether;4-chlorophenyl4’-nitrophenylether;ether,p-chlorophenylp-nitrophenyl;1-(4-CHLOROPHENOXY)-4-NITROBENZENE;4-Chloro-4'-nitrodiphenyl ether;4-Nitro-4-chloro-diphenyl ether;(4-Nitrophenyl)(4-chlorophenyl) ether
• CAS NO: 1836-74-4
• Molecular Formula: C₁₂H₈ClNO₃
• Molecular Weight: 249.65
• EINECS: 217-405-5
• Mol File: 1836-74-4.mol
• Article Data: 44

Chemical Properties

• Melting Point: 76.5 °C
• Boiling Point: 350.032 °C at 760 mmHg
• Flash Point: 165.494 °C
• Appearance: /
• Density: 1.358 g/cm³
• Vapor Pressure: 1.28E-08mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1-(4-Chlorophenoxy)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorophenoxy)-4-nitrobenzene(1836-74-4)
• EPA Substance Registry System: 1-(4-Chlorophenoxy)-4-nitrobenzene(1836-74-4)

Safety Data

• Hazardous Substances Data: 1836-74-4(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenoxy)-4-nitrobenzene is a chemical compound that falls under the category of organochlorine compounds, which primarily includes carbon-based molecules with at least one chlorine atom. The presence of a nitro group and a chloro group suggests that this compound could exhibit both electrophilic and nucleophilic properties due to the polar effect of these groups. It could possibly be used in the synthesis of various organic substances such as dyes, pharmaceuticals, and pesticides due to its structure. Like other chlorinated aromatic compounds, it's advisable to handle it with care due to potential toxicity. However, specific information regarding its toxicity, environmental impact, and detailed uses are not widely documented, due to which its usage or effects may not be fully known.

InChI:InChI=1/C5H6N2O/c6-5-2-1-4(8)3-7-5/h1-3,8H,(H2,6,7)

Upstream product

• 7005-72-3 4-chlorodiphenyl ether 
• 620-88-2 4-nitrophenyl phenyl ether 
• 106-48-9 4-chloro-phenol 
• 350-46-9 4-Fluoronitrobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 1193-00-6 sodium 4-chlorophenolate 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 7697-37-2 nitric acid 
• 108-24-7 acetic anhydride 
• 586-78-7 para-nitrophenyl bromide 
• 100-02-7 4-nitro-phenol 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 6317-27-7 p-chlorophenyl mesylate 

Downstream Products

• 347339-21-3 N-(4-(4-chlorophenoxy)phenyl)benzamide 
• 122947-59-5 4-(4-Chloro-phenoxy)-2-dichloromethyl-1-nitro-benzene 
• 28232-53-3 3-(4-nitro-phenoxy)-pyridine 
• 2005-08-5 4-chlorophenyl benzoate 
• 1438233-90-9 (E)-N-(7-chloro-1-ethylquinolin-4(1H)-ylidene)-4-(4-chlorophenoxy)aniline trifluoromethanesulfonate 
• 68253-29-2 4-Dimethylamino-4'-chlor-diphenylether 
• 51338-03-5 (+/-)-2-[4-(4-chlorophenoxy)-phenylthio]-propionic acid 
• 59621-43-1 2-[4-(4-Chloro-phenoxy)-phenylsulfanyl]-N-(2-hydroxy-ethyl)-acetamide 
• 59621-46-4 2-[4-(4-Chloro-phenoxy)-phenylsulfanyl]-2-methyl-propionic acid 

Relevant articles and documents

Novel cobalt-valine catalyzed O-arylation of phenols with electron deficient aryl iodides

Abstract: A Novel cobalt-catalyzed O-arylation of phenols with electron deficient aryl iodides is described. The reaction employs cheap and easy-to-handle cobalt acetate tetrahydrate as the catalyst precursor and naturally occurring l-valine as the ligand without the use of any transmetallating or reducing agents. The new protocol offers a wide scope for a variety of phenols towards O-arylation with moderate to excellent yields with electron deficient aryl iodides.

Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model

SARS-CoV-2 virus has recently given rise to the current COVID-19 pandemic where infected individuals can range from being asymptomatic, yet highly contagious, to dying from acute respiratory distress syndrome. Although the world has mobilized to create antiviral vaccines and therapeutics to combat the scourge, their long-term efficacy remains in question especially with the emergence of new variants. In this work, we exploit a class of compounds that has previously shown success against various viruses. A salicylanilide library was first screened in a SARS-CoV-2 activity assay in Vero cells. The most efficacious derivative was further evaluated in a prophylactic mouse model of SARS-CoV-2 infection unveiling a salicylanilide that can reduce viral loads, modulate key cytokines, and mitigate severe weight loss involved in COVID-19 infections. The combination of anti-SARS-CoV-2 activity, cytokine inhibitory activity, and a previously established favorable pharmacokinetic profile for the lead salicylanilide renders salicylanilides in general as promising therapeutics for COVID-19.

CoII Immobilized on Aminated Magnetic-Based Metal–Organic Framework: An Efficient Heterogeneous Nanostructured Catalyst for the C–O Cross-Coupling Reaction in Solvent-Free Conditions

Abstract: In this paper, we report the synthesis of Fe3O4?AMCA-MIL53(Al)-NH2-CoII NPs based on the metal–organic framework structures as a magnetically separable and environmentally friendly heterogeneous nanocatalyst. The prepared nanostructured catalyst efficiently promotes the C–O cross-coupling reaction in solvent-free conditions without the need for using toxic solvents and/or expensive palladium catalyst. Graphic Abstract: [Figure not available: see fulltext.].

Cu(I)-PNF, an organic-based nanocatalyst, catalyzed C-O and C-S cross-coupling reactions

Peptide nanofiber has been prepared via a self-assembly protocol and decorated with Cu(I) to prepare a nanostructural catalyst. The catalytic activity of this prepared nanomaterial (Cu(I)-PNF) was examined in C-O and C-S cross-coupling reactions. Compared with conventional copper-ligand catalytic systems, CuNP-PNF has unique advantages such as water solubility, high efficiency, and low cost, which makes it a highly efficient and beneficial catalyst to reuse in cross-coupling reactions.