1840-00-2

Basic information

• Product Name: 3-(3-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
• Synonyms: 3-(3-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
• CAS NO: 1840-00-2
• Molecular Weight: 242.25
• Mol File: 1840-00-2.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 3-(3-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one(1840-00-2)
• EPA Substance Registry System: 3-(3-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one(1840-00-2)

Safety Data

• Hazardous Substances Data: 1840-00-2(Hazardous Substances Data)

Upstream product

• 1678-20-2 2-(3-fluorophenyl)chroman-4-one 
• 118-93-4 o-hydroxyacetophenone 
• 456-48-4 3-Fluorobenzaldehyde 

Downstream Products

• 364-55-6 3-hydroxy-2-(3-fluorophenyl)-chromen-4(1H)-one 
• 1678-20-2 2-(3-fluorophenyl)chroman-4-one 
• 1744-33-8 3'-Fluoroflavone 
• 59500-93-5 3-(3-fluorophenyl)-1-(2-hydroxyphenyl)propan-1-one 
• 1610536-07-6 (+)-2-(3-fluorophenyl)chroman-4-one 
• 1046471-37-7 4-chloro-2-(3-fluorophenyl)-2H-chromene 

Relevant articles and documents

Stereoselective reduction of flavanones by marine-derived fungi

Biotransformation is an alternative with great potential to modify the structures of natural and synthetic flavonoids. Therefore, the bioreduction of synthetic halogenated flavanones employing marine-derived fungi was described, aiming the synthesis of flavan-4-ols 3a-g with high enantiomeric excesses (ee) of both cis- and trans-diastereoisomers (up to >99% ee). Ten strains were screened for reduction of flavanone 2a in liquid medium and in phosphate buffer solution. The most selective strains Cladosporium sp. CBMAI 1237 and Acremonium sp. CBMAI1676 were employed for reduction of flavanones 2a-g. The fungus Cladosporium sp. CBMAI 1237 presented yields of 72–87% with 0–64% ee cis and 0–30% ee trans with diastereoisomeric ratio (dr) from 52:48 to 64:36 (cis:trans). Whereas Acremonium sp. CBMAI 1676 resulted in 31% yield with 77–99% ee of the cis and 95–99% ee of the trans-diastereoisomers 3a-g with a dr from 54:46 to 96:4 (cis:trans). To our knowledge, this is the first report of the brominated flavon-4-ols 3e and 3f. The use of fungi, with emphasis for these marine-derived strains, is an interesting approach for enantioselective reduction of halogenated flavanones. Therefore, this strategy can be explored to obtain enantioenriched compounds with biological activities.

Synthesis and characterization of some new pyrazolines and their inhibitory potencies against carbonic anhydrases

The inhibition of the two human cytosolic carbonic anhydrase (hCA; EC 4.2.1.1) isozymes I and II with some new pyrazoline derivatives was investigated for the first time. The structures of the newly synthesized pyrazoline derivatives were characterized by

Halo-substituted chalcones and azachalcones-inhibited, lipopolysaccharited-stimulated, pro-inflammatory responses through the TLR4-mediated pathway

A series of B-ring, halo-substituted chalcones and azachalcones were synthesized to evaluate and compare their anti-inflammatory activity. Mouse BALB/c macrophage RAW 264.7 were pre-treated with 10 μg/mL of each compound for one hour before induction of i