185454-47-1Relevant articles and documents
Synthesis of terfenadine carboxylate
Patel, Sunil,Waykole, Liladhar,Repic, Oljan,Chen, Kau-Ming
, p. 4699 - 4710 (1996)
A synthesis of terfenadine carboxylate, 1, a metabolite of terfenadine 2, is described. In the key step, the sodium salt of 2-(4-bromo-phenyl)-2-methylpropionic acid, 7, was lithiated via a metal-halogen exchange using t-BuLi and subsequently condensed with 4-[4-(hydroxydiphenylmethylpiperidin-1-yl]butyraldehyde, 5, to afford terfenadine carboxylate, 1.