186020-66-6 Usage
Description
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-, also known as Hydroxy-PEG3-t-butyl ester, is a PEG (polyethylene glycol) linker that contains a hydroxyl group with a t-butyl ester. This molecule is characterized by its hydrophilic PEG spacer, which enhances solubility in aqueous media, and a t-butyl protected carboxyl group that can be deprotected under acidic conditions. The presence of the hydroxyl group allows for further derivatization or replacement with other reactive functional groups, making it a versatile compound for various applications.
Uses
Used in Pharmaceutical Industry:
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXAis used as a solubility enhancer for improving the aqueous solubility of hydrophobic drugs. The hydrophilic PEG spacer increases the drug's interaction with water, facilitating better dissolution and absorption.
Used in Chemical Synthesis:
In the field of chemical synthesis, TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXAserves as a versatile building block for the creation of more complex molecules. The hydroxyl group can be further derivatized or replaced with other reactive functional groups, allowing for the development of new compounds with specific properties and applications.
Used in Drug Delivery Systems:
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXAis used as a component in the design of drug delivery systems. The t-butyl protected carboxyl group can be deprotected under acidic conditions, allowing for the controlled release of drugs in specific environments, such as the acidic conditions of tumor tissues or the endosome/lysosome compartments in cells.
Used in Bioconjugation:
In the field of bioconjugation, TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXAis used as a linker to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The hydroxyl group provides a reactive site for covalent attachment, enabling the creation of conjugates with specific properties and functions.
Check Digit Verification of cas no
The CAS Registry Mumber 186020-66-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,0,2 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 186020-66:
(8*1)+(7*8)+(6*6)+(5*0)+(4*2)+(3*0)+(2*6)+(1*6)=126
126 % 10 = 6
So 186020-66-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H26O6/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h14H,4-11H2,1-3H3
186020-66-6Relevant articles and documents
A 18F-labeled dibenzocyclooctyne (DBCO) derivative for copper-free click labeling of biomolecules
Kettenbach,Ross
, p. 654 - 657 (2016)
The new prosthetic group 18F-TEG-DBCO (dibenzocyclooctyne) can be prepared within a total reaction time of 60 min including purification with an overall yield (n.d.c.) of 34 ± 5%. Copper-free click cycloadditions with an azido-cRGD, a folate-az
PROTAC small molecular compound and application thereof
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Paragraph 0235-0237, (2021/03/30)
The invention discloses a compound with a general formula I, or a pharmaceutically acceptable salt, a stereoisomer, an ester, a prodrug, a solvate and a deuterated compound thereof, a composition containing the compound with the general formula I, and application of the compound with the general formula I or the pharmaceutically acceptable salt, stereoisomer, ester, prodrug, solvate and deuteratedcompound thereof in preparation of medicines for treating diseases related to serine/threonine kinase family (MAP4Ks), preferably medicines for treating diseases related to hematopoietic stem cell kinase 1 (HPK1).
A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS
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Page/Page column 240-241, (2021/01/23)
Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.
