1862-07-3

Basic information

• Product Name: 6-DIMETHYLAMINO-1-HEXANOL
• Synonyms: dimethylaminohexanol;6-DIMETHYLAMINO-1-HEXANOL;6-(DIMETHYLAMINO) HEXANOL-1;6-DIMETHYLAMINO-1-HEXANOL 97+%;6-dimethylaminohexan-1-ol;(6-Hydroxyhexyl)diMethylaMine;6-(DiMethylaMino)hexanol;Kao 25
• CAS NO: 1862-07-3
• Molecular Formula: C₈H₁₉NO
• Molecular Weight: 145.24
• EINECS: 404-680-3
• Product Categories: Aliphatics;Amines;Inhibitors
• Mol File: 1862-07-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 117 °C / 12mmHg
• Flash Point: 63.6°C
• Appearance: /
• Density: 0,88 g/cm3
• Vapor Pressure: 0.0656mmHg at 25°C
• Refractive Index: 1.4460-1.4500
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: 15.19±0.10(Predicted)
• CAS DataBase Reference: 6-DIMETHYLAMINO-1-HEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-DIMETHYLAMINO-1-HEXANOL(1862-07-3)
• EPA Substance Registry System: 6-DIMETHYLAMINO-1-HEXANOL(1862-07-3)

Safety Data

• Hazard Codes: C
• Statements: 10-20/21/22-34-52/53-22
• Safety Statements: 16-26-36/37/39-45-61
• RIDADR: 2733
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 1862-07-3(Hazardous Substances Data)

Usage

Description

6-DIMETHYLAMINO-1-HEXANOL is an alkanolamine with the chemical properties of a clear, colorless liquid. It is known for its ability to act as a lysosomotropic agent and a choline uptake inhibitor, making it a versatile compound with potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
6-DIMETHYLAMINO-1-HEXANOL is used as a lysosomotropic agent for its ability to target and affect the function of lysosomes within cells. This application is particularly relevant in the development of treatments for various diseases, as lysosomal dysfunction has been linked to several pathological conditions.
6-DIMETHYLAMINO-1-HEXANOL is also used as a choline uptake inhibitor, which can be beneficial in the development of drugs targeting neurological disorders and other conditions related to choline metabolism.
Used in Chemical Industry:
In the chemical industry, 6-DIMETHYLAMINO-1-HEXANOL's clear, colorless liquid properties make it a suitable candidate for use as a solvent or reagent in various chemical processes. Its alkanolamine structure also allows for potential use in the synthesis of other compounds or materials.
Used in Research and Development:
6-DIMETHYLAMINO-1-HEXANOL's unique properties as a lysosomotropic agent and choline uptake inhibitor make it a valuable tool in research and development for understanding the underlying mechanisms of various biological processes and the development of novel therapeutic strategies.

InChI:InChI=1/C8H19NO/c1-9(2)7-5-3-4-6-8-10/h10H,3-8H2,1-2H3

Upstream product

• 2009-83-8 6-chloro-1-hexanol 
• 52254-56-5 N,N-dimethyhex-5-enylamine 
• 67-56-1 methanol 
• 4048-33-3 6-amino-1-hexanol 
• 629-11-8 1,6-hexanediol 
• 124-40-3 dimethyl amine 
• 50-00-0 formaldehyd 
• 626-86-8 adipinic acid monoethyl ester 
• 1071-71-2 ethyl 6-chloro-6-oxohexanoate 
• 50347-17-6 N-Methyl-6-hydroxyhexylamine 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 4286-55-9 1-bromo-6-hexanol 
• 87876-65-1 Acetate(6-hydroxy-hexyl)-trimethyl-ammonium; 
• 58390-11-7 (6-Hydroxy-hexyl)-trimethyl-ammonium; hydroxide 

Downstream Products

• 80389-23-7 bis[6-(N,N-dimethylamino)hexyl] disulfide 
• 220823-39-2 6-(N,N-dimethylamino)hexyl octyl fumarate 
• 220823-36-9 2-[6-(N,N-dimethylamino)hexylthio]-3-dimethyloctylsilyl-1,3-butadiene 
• 1201798-14-2 C₇H₇O₃S^(1-)*C₂₀H₄₄NO⁽¹⁺⁾ 
• 1238673-11-4 7-(6-(dimethylamino)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine 
• 20602-93-1 6-dimethylaminohexyl methacrylate 
• 1938-58-5 N,N-dimethyl-1,6-hexanediamine 
• 2554-94-1 6-Dimethylamino-1-hexanal 
• 1373766-78-9 6-(dimethylamino)hexyl 7-methoxy-4-oxo-2-(3-phenoxyphenyl)-1,4-dihydroquinoline-3-carboxylate 
• 1352656-12-2 6-(N,N-dimethylamino)hexyl bicyclo[2.2.1]hept-5-ene-2-carboxylate 
• 1307864-14-7 C₃₃H₃₈N₂O₆ 
• 1307863-84-8 C₄₀H₅₃N₃O₆ 
• 1307864-01-2 C₃₂H₃₆N₂O₅ 
• 1307864-17-0 AZC₆M-AE-NHS 

Relevant articles and documents

Regioselectivity control in Diels-Alder reactions of surfactant 1,3- dienes with surfactant dienophiles

The ability of surfactant aggregate-H2O interfaces to control the regioselectivity of Diels-Alder reactions has been investigated. Cycloadditions of surfactant 1,3-dienes 2-[[3-(dimethyldodecylsilyl)-1,3- butadien-2-yl]thio]-N,N,N-trimethyl-1-ethanaminium iodide (1a) and 6-[[3- (dimethyloctylsilyl)-1,3-butadien-2-yl]thio]-N,N,N-trimethyl-1-hexanaminium iodide (1b) with surfactant dienophiles (E)-2-[[[2- (dodecoxycarbonyl)ethenyl]carbonyl]oxy]-N,N,N-trimethyl-1-ethanaminium iodide (2a) and (E)-6-[[[2-(octoxycarbonyl)ethenyl]carbonyl]oxy]-N,N,N-trimethyl-1- hexanaminium bromide (2b) within their aqueous mixed micelles have been performed at 25(35) °C. The cycloaddition of 1a and 2a gave a 30:1 ratio of trans-1-[(2-trimethylammonio)ethylthio]-2-(dimethyldodecylsilyl)-4- (dodecoxycarbonyl)-5-[(2-trimethylammonio)ethoxycarbonyl]-1-cyclohexene dihalide (15a) and trans-1-[(2-trimethylammonio)ethylthio]-2- (dimethyldodecylsilyl)-4-[(2-trimethylammonio)ethoxycarbonyl]-5- (dodecoxycarbonyl)-1-cyclohexene dihalide (16a), respectively, and that of 1b and 2b a 6.6:1 ratio of trans-1-[(6-trimethylammonio)hexylthio]-2- (dimethyloctylsilyl)-4-(octoxycarbonyl)-5-[6- (trimethylammonio)hexoxycarbonyl]-1-cyclohexene dihalide (15b) and trans-1- [(6-trimethylammonio)hexylthio]-2-(dimethyloctylsilyl)-4-[6- (trimethylammonio)hexoxycarbonyl]-5-(octoxycarbonyl)-1-cyclohexene dihalide (16b), respectively. The excess of 15 over 16 is consistent with the reaction of 1 and 2 within mixed aggregates in their preferred orientations at the aggregate-H2O interface. The greater regioselectivity obtained in the reaction of 1a and 2a is ascribed to the shorter tether between their reactive functional groups and quaternary ammonium headgroups. A monolayer study of 15a and 16a was also performed.

Catalytic Hydrogenation of Thioesters, Thiocarbamates, and Thioamides

Direct hydrogenation of thioesters with H2 provides a facile and waste-free method to access alcohols and thiols. However, no report of this reaction is documented, possibly because of the incompatibility of the generated thiol with typical hydrogenation catalysts. Here, we report an efficient and selective hydrogenation of thioesters. The reaction is catalyzed by an acridine-based ruthenium complex without additives. Various thioesters were fully hydrogenated to the corresponding alcohols and thiols with excellent tolerance for amide, ester, and carboxylic acid groups. Thiocarbamates and thioamides also undergo hydrogenation under similar conditions, substantially extending the application of hydrogenation of organosulfur compounds.

METHOD OF PRODUCING TERTIARY AMINE OR TERTIARY AMINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method of producing tertiary amine or tertiary amine derivative with high selectivity. SOLUTION: In the method of producing tertiary amine or tertiary amine derivative, a reaction system including: an organic chemical raw material containing at least one kind of group selected from -NH2, -NH2 HCl, >NH and >NH HCl, a nitrogen atom contained in the group bounding to a carbon atom; aliphatic alcohol having 1 to 20 carbon atoms; and a catalyst where a carrier containing titanium oxide carries a silver component (metal silver or silver compound), is irradiated with light, and the group in the organic compound raw material is converted to -NR02 or >NR0, ( R0 is an aliphatic hydrocarbon group having 1 to 20 carbon atoms derived from the aliphatic alcohol). The percentage content of the silver in the catalyst is 0.5 to 10 mass% with respect to the titanium oxide. COPYRIGHT: (C)2015,JPOandINPIT

Synthesis and biological activity of dialkylphosphocholines

A series of dialkylphosphocholines were prepared and evaluated for their biological activity. The antiprotozoal activity was determined against Acanthamoeba lugdunensis. Compound 15 exhibited excellent trophocidal activity. None of the tested dialkylphosphocholines exhibited better fungicidal activity against Candida albicans than miltefosine. The antineoplastic activity was determined against HeLa. The most cytotoxic was compound 10, which was more active against tumor cells as against normal cells.