18859-20-6

Basic information

• Product Name: N-methyl-N,3-diphenylpropanamide
• Synonyms: benzenepropanamide, N-methyl-N-phenyl-; N-Methyl-N,3-diphenylpropanamide
• CAS NO: 18859-20-6
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.3123
• Mol File: 18859-20-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 374.4°C at 760 mmHg
• Flash Point: 168.2°C
• Density: 1.096g/cm³
• Vapor Pressure: 8.39E-06mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: N-methyl-N,3-diphenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N,3-diphenylpropanamide(18859-20-6)
• EPA Substance Registry System: N-methyl-N,3-diphenylpropanamide(18859-20-6)

Safety Data

• Hazardous Substances Data: 18859-20-6(Hazardous Substances Data)

Upstream product

• 121-69-7 N,N-dimethyl-aniline 
• 501-52-0 3-Phenylpropionic acid 
• 4250-02-6 1-diazo-3-phenyl-2-propanone 
• 100-61-8 N-methylaniline 
• 151418-18-7 Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid 
• 645-45-4 hydrocinnamic acid chloride 
• 614-30-2 N-methyl-N-phenyl-benzenemethanamine 
• 120568-26-5 (E)-2-(methyl(phenyl)amino)-4-phenylbut-3-enenitrile 
• 147471-27-0 (Z)-2-(N-methylanilino)-4-phenyl-2-butenenitrile 
• 33603-46-2 (E)-N-methyl-N-phenylcinnamamide 
• 89585-53-5 3-chloro-N-methyl-N-phenylpropanamide 
• 98-80-6 phenylboronic acid 
• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 6273-94-5 N-methyl-N-phenylacrylamide 

Downstream Products

• 104-53-0 3-phenyl-propionaldehyde 
• 6047-99-0 1-phenyloctan-3-one 
• 29514-68-9 N-methyl-N-phenyl-3-phenylpropylamine 
• 43125-06-0 1-cyclohexyl-3-phenyl-1-propanone 
• 20627-49-0 3-phenyl-propionic acid butyl ester 
• 108357-95-5 1,5-diphenylpent-1-yn-3-one 

Relevant articles and documents

Enantioselective borohydride 1,4-reduction of α,β-unsaturated carboxamides using optically active cobalt(II) complex catalysts

The enantioselective borohydride reduction catalyzed by cobalt(II) complex was successfully applied to 1,4-reduction of β,β-disubstituted α,β-unsaturated carboxamides. In the presence of less than 1 mol% of optically active aldiminato cobalt(II) complex c

Manganese(I) Catalyzed α-Alkenylation of Amides Using Alcohols with Liberation of Hydrogen and Water

Herein, unprecedented manganese-catalyzed direct α-alkenylation of amides using alcohols is reported. Aryl amides are reacted with diverse primary alcohols, which provided the α,β-unsaturated amides in moderate to good yields with excellent selectivity. Mechanistic studies indicate that Mn(I) catalyst oxidizes the alcohols to their corresponding aldehydes and also plays an important role in efficient C═C bond formation through aldol condensation. This selective olefination is facilitated by metal-ligand cooperation by the aromatization-dearomatization process operating in the catalytic system. Biorenewable alcohols are used as alkenylation reagents for the challenging α-alkenylation of amides with the highly abundant base metal manganese as a catalyst, which results in water and dihydrogen as the only byproduct, making this catalytic transformation attractive, sustainable, and environmentally benign.

method for alpha-alkylation of acetamides and thioacetamides under catalysis of nickel

The invention discloses a method for alpha-alkylation of acetamide and thioacetamide under the catalysis of nickel. The method comprises the following steps: by taking a complex generated in situ by adivalent nickel salt and a phosphine ligand as a catalyst and primary alcohol as an alkylation reagent, performing alpha-alkylation reaction on acetamide or thioacetamide in an alkaline environment to prepare amide or thioamide. According to the alpha-alkylation reaction of acetamide and thioacetamide, the active catalyst can be generated in situ from a bivalent nickel salt and a phosphine ligand, so that the catalyst is prevented from being prepared in advance, the operation is simple and convenient, and experimental steps and cost are saved.