189628-37-3

Basic information

• Product Name: 5-BROMO-2-CHLOROBENZALDEHYDE
• Synonyms: 2-chloro-5-bromobenzaldehyde;Benzaldehyde, 5-broMo-2-chloro-;5-BroMo-2-chlorobenzaldehyde, 97+%
• CAS NO: 189628-37-3
• Molecular Formula: C₇H₄BrClO
• Molecular Weight: 219.47
• Mol File: 189628-37-3.mol
• Article Data: 17

Chemical Properties

• Melting Point: 43-46℃
• Boiling Point: 261℃
• Flash Point: 112℃
• Appearance: Off-white to pale yellow/Solid
• Density: 1.698
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-BROMO-2-CHLOROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLOROBENZALDEHYDE(189628-37-3)
• EPA Substance Registry System: 5-BROMO-2-CHLOROBENZALDEHYDE(189628-37-3)

Safety Data

• Hazard Codes: Xi,E
• Hazardous Substances Data: 189628-37-3(Hazardous Substances Data)

Usage

Description

5-BROMO-2-CHLOROBENZALDEHYDE is an organic compound that serves as an intermediate in various organic syntheses. It is characterized by its white crystalline appearance and possesses unique chemical properties that make it valuable in the synthesis of a range of organic compounds.

Uses

Used in Organic Synthesis:
5-BROMO-2-CHLOROBENZALDEHYDE is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the formation of a wide range of products through chemical reactions, making it a versatile building block in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-BROMO-2-CHLOROBENZALDEHYDE is used as a precursor in the synthesis of various pharmaceutical compounds. Its ability to participate in a variety of chemical reactions enables the creation of new drugs with potential therapeutic applications.
Used in Chemical Research:
5-BROMO-2-CHLOROBENZALDEHYDE is also utilized in chemical research for the study of reaction mechanisms and the development of new synthetic methods. Its unique properties make it an interesting subject for researchers looking to explore new avenues in organic chemistry.
Used in Agrochemical Industry:
In the agrochemical industry, 5-BROMO-2-CHLOROBENZALDEHYDE is employed as an intermediate in the synthesis of various agrochemicals, such as pesticides and herbicides. Its versatility in organic synthesis allows for the development of new and effective products for agricultural use.
Used in Dye and Pigment Industry:
5-BROMO-2-CHLOROBENZALDEHYDE is used as an intermediate in the production of dyes and pigments. Its ability to form a wide range of organic compounds makes it a valuable component in the creation of various colorants for use in different industries, such as textiles, plastics, and printing inks.

InChI:InChI=1/C7H4BrClO/c8-6-1-2-7(9)5(3-6)4-10/h1-4H

Upstream product

• 842136-59-8 5-bromo-2-chloro-N-methoxy-N-methyl-benzamide 
• 251085-87-7 methyl 5-bromo-2-chloro-benzoate 
• 21739-92-4 5-bromo-2-chlorobenzoic acid 
• 149965-40-2 5-bromo-2-chlorobenzyl alcohol 
• 3132-99-8 m-bromobenzoic aldehyde 
• 89-98-5 2-chloro-benzaldehyde 
• 21900-52-7 5-bromo-2-chloro-benzoyl chloride 

Downstream Products

• 784144-30-5 (5-bromo-2-chloro-phenyl)-(4-bromo-phenyl)-methanol 
• 724768-03-0 (5-bromo-2-chloro-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanol 
• 761425-04-1 1-benzothiophen-2-yl-(5-bromo-2-chlorophenyl)methanol 
• 914106-04-0 5-bromo-2-chlorobenzaldehyde chlorooxime 
• 914106-15-3 3-(5-bromo-2-chlorophenyl)-5-(4-cyanophenyl)isoxazole 
• 914105-96-7 3-(2-chloro-5-cyanophenyl)-5-(4-cyanophenyl)isoxazole 
• 724767-82-2 (5-bromo-2-chloro-phenyl)-(4-bromo-phenyl)-methanone 
• 724767-85-5 (5-bromo-2-chloro-phenyl)-[4-(2,4-difluoro-phenylamino)-phenyl]-methanone 
• 749932-77-2 1-(5-bromo-2-chlorophenyl)ethan-1-ol 
• 540778-90-3 ethyl (E)-5-bromo-2-chlorocinnamate 
• 1073494-42-4 (Z)-ethyl 2-azido-3-(5-bromo-2-chlorophenyl)acrylate 
• 874650-46-1 1-bromo-4-chloro-3-cyclohexylidenemethyl-benzene 
• 842136-72-5 (5-bromo-2-chlorophenyl)(1-phenyl-1H-pyrazol-4-yl)methanol 
• 1291094-48-8 (4-benzylspiro[3H-1,4-benzoxazine-2,1'-cyclopropane]-6-yl)-(5-bromo-2-chloro-phenyl)methanol 

Relevant articles and documents

Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C-H Methoxylation and Chlorination of Benzaldehydes

We report Pd-catalyzed ortho-C-H methoxylation and chlorination of benzaldehydes by employing monodentate transient directing groups (TDGs) as an alternative strategy to bidentate TDGs. More importantly, a single crystal of benzaldehyde imine ortho-cyclopalladium intermediate was successfully obtained, and its structure was unambiguously determined by X-ray diffraction, which clearly showed that it was a binuclear palladium species bridged by a pyridone ligand. The utility of this approach was further demonstrated through the synthesis of key intermediates of natural products and drugs.

NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF

The present invention generally relates to an improved process for the preparation of dapagliflozin of Formula I or its solvates or co-crystals thereof. The present invention also encompasses the novel intermediates and their use in the preparation of dap

Preparation method of empagliflozin

The invention relates to a preparation method of empagliflozin. The preparation method of empagliflozin comprises the following steps: taking 2-chlorobenzaldehyde as a starting material; carrying outbromination reaction, reduction reaction and halogenating reaction on the starting material, and carrying out Friedel-Crafts alkylation reaction on the starting material and (S)-3-phenoxyl tetrahydrofuran to obtain an intermediate which is (S)-3-(4-(5-bromo-2-chlorobenzyl) phenoxyl) tetrahydrofuran; and then carrying out condensation, etherification and methoxyl removal on the intermediate and 2,3,4,6-quadri-O-trimethylsilyl-D-glucolactone to obtain the empagliflozin as a hypoglycemic drug. The preparation method of the empagliflozin has the advantages that compared with an existing synthesisprocess, the preparation method of the empagliflozin takes the 2-chlorobenzaldehyde as the starting material, raw materials are cheap and easy to obtain, industrialization is easy to implement in theprocess, the synthesis route is short, and the method is easy to operate; in a preparation process, various temperature conditions are easy to control, reaction conversion rate is high, and the totalyield can be 75% or above; and moreover, by the preparation method, the product cannot be isomerized easily, impurities are fewer, the purity of the product can be improved, and the purity can be 99%or above.