193611-72-2

Basic information

• Product Name: BRL 15572 HYDROCHLORIDE
• Synonyms: 3-(4-(3-chlorophenyl)piperazin-1-yl)-1,1-diphenylpropan-2-ol dihydrochloride;BRL 15572 HYDROCHLORIDE;3-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]-1,1-DIPHENYL-2-PROPANOL HCL;3-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]-1,1-DIPHENYL-2-PROPANOL HYDROCHLORIDE;BRL15572HCl;BRL-15572 (dihydrochloride);4-(3-Chlorophenyl)-alpha-(diphenylmethyl)-1-piperazineethanol dihydrochloride
• CAS NO: 193611-72-2
• Molecular Formula: C25H28Cl2N2O
• Molecular Weight: 443.41
• Product Categories: Inhibitors;Serotonin receptor
• Mol File: 193611-72-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 580.7°C at 760 mmHg
• Flash Point: 305°C
• Appearance: /
• Vapor Pressure: 2.51E-14mmHg at 25°C
• Storage Temp.: Desiccate at +4°C
• Solubility: Soluble in DMSO
• CAS DataBase Reference: BRL 15572 HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BRL 15572 HYDROCHLORIDE(193611-72-2)
• EPA Substance Registry System: BRL 15572 HYDROCHLORIDE(193611-72-2)

Safety Data

• Hazardous Substances Data: 193611-72-2(Hazardous Substances Data)

Usage

Description

BRL 15572 HYDROCHLORIDE is an analog of BRL 15572, which functions as a preferential antagonist at native human 5-HT1D receptors. It is a chemical compound with potential applications in various industries due to its specific receptor interaction.

Uses

Used in Pharmaceutical Industry:
BRL 15572 HYDROCHLORIDE is used as a pharmacological agent for targeting 5-HT1D receptors. Its application reason is to potentially aid in the development of treatments for conditions related to the serotonin system, such as migraines, depression, and anxiety disorders.
Used in Research and Development:
In the field of research and development, BRL 15572 HYDROCHLORIDE is used as a research tool for studying the role and function of 5-HT1D receptors in various physiological and pathological processes. This application helps scientists to better understand the receptor's involvement in different conditions and to develop more effective drugs targeting these receptors.
Used in Drug Discovery:
BRL 15572 HYDROCHLORIDE is used as a lead compound in drug discovery for the development of new medications that can modulate the activity of 5-HT1D receptors. Its application reason is to potentially create novel therapeutics that can treat a range of disorders associated with serotonin signaling.

Biological Activity

A selective h5-HT 1D antagonist, displaying 60-fold selectivity over h5-HT 1B , and exhibiting little or no affinity for a range of other receptor types.

references

[1] price g w, burton m j, collin l j, et al. sb-216641 and brl-15572–compounds to pharmacologically discriminate h5-ht1b and h5-ht1d receptors. naunyn-schmiedeberg's archives of pharmacology, 1997, 356(3): 312-320.

InChI:InChI=1/C25H27ClN2O.ClH/c26-22-12-7-13-23(18-22)28-16-14-27(15-17-28)19-24(29)25(20-8-3-1-4-9-20)21-10-5-2-6-11-21;/h1-13,18,24-25,29H,14-17,19H2;1H