2028-85-5

Basic information

• Product Name: 4-bromobenzenediazonium chloride
• CAS NO: 2028-85-5
• Molecular Formula: C₆H₄BrN₂*Cl
• Molecular Weight: 219.4664
• Mol File: 2028-85-5.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: 4-bromobenzenediazonium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromobenzenediazonium chloride(2028-85-5)
• EPA Substance Registry System: 4-bromobenzenediazonium chloride(2028-85-5)

Safety Data

• Hazardous Substances Data: 2028-85-5(Hazardous Substances Data)

Upstream product

• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 18068-34-3 (4-bromo-phenyl)-sulfinyl-hydrazine 
• 100-63-0 phenylhydrazine 
• 3470-38-0 1,3-bis-(4-bromo-phenyl)-triazene 
• 780-20-1 N-benzylidene-4-bromoaniline 
• 589-21-9 (4-bromophenyl)hydrazine 
• 106-40-1 4-bromo-aniline 
• 624-19-1 4-bromoaniline hydrochloride 
• 7647-01-0 hydrogenchloride 
• 763910-59-4 N-(4-bromo-phenyl)-N-nitroso-hydroxylamine 
• 67959-26-6 C₁₄H₁₁BrN₄S 
• 67959-25-5 2-[(1Ξ,2E)-(4-bromo-phenyl)-triazenylidene]-3-methyl-2,3-dihydro-benzothiazole 
• 110-46-3 isopentyl nitrite 

Downstream Products

• 87261-59-4 1-(4-bromo-phenylazo)-piperidine 
• 21724-96-9 3-(4-bromophenyl)-1H-pyrrole-2,5-dione 
• 27143-10-8 ethoxycarbonylformyl chloride p-bromophenylhydrazone 
• 98590-49-9 1-(4-bromo-phenylhydrazono)-1-nitro-acetone 
• 91417-72-0 benzothiazol-2-yl-(4-bromo-phenylhydrazono)-acetonitrile 
• 861325-12-4 2-(4-bromo-phenylazo)-4-methyl-1⁽³⁾H-imidazole 
• 108-86-1 bromobenzene 
• 860256-21-9 2-(4-bromobenzyl)acrylic acid 
• 5756-88-7 1-(4-bromophenyl)-3-phenyl-3-hydroxytriazene 
• 41798-85-0 1,5-bis-(4-bromo-phenyl)-3-methyl-pentaaza-1,4-diene 

Relevant articles and documents

PROCESS FOR THE SYNTHESIS OF ARYLDIAZONIUM SALTS USING NITROGEN OXIDES IN OXYGEN-CONTAINING GAS STREAMS, ESPECIALLY FROM INDUSTRIAL WASTE GASES

The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.

Design, synthesis and anticancer activity of some novel 5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one derivatives

New pyrazole derivatives were designed and synthesized by the reaction of 5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one (4) or 5-(4-methoxyphenyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (5) with series of aldehydes, substituted amines, isatins and phenylisothiocynate to yield 6a-j, 7a-k, 9a-d and 10a-b, respectively. The synthesized compounds were examined in vitro for their anti-tumor activities against HepG-2, PC-3 and HCT-116 human carcinoma cell lines using MTT assay. Eight compounds showed good anticancer activities against HCT-116 carcinoma cells and five compounds showed good anticancer activities against PC-3 cancer cells but all the compounds showed weak or no anticancer activities against HepG-2 liver cancer.

Synthesis, in vitro and in Silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents

In this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative 21f exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06-0.98 μg/mL and antimycobacterial activity with MIC=3.9 μg/mL. The 5-nitrofuran-2-carbohydrazides 21a, b, g, h and 22a-c exhibited significant antibacterial activity with MIC values in the range of 0.12-7.81 μg/mL. The significances of the 5-nitrofuran moiety and sulfonamide function were explored via the structure-activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound 21f. Furthermore, two quantitative structure-activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.