20398-06-5 Usage
Description
Thallium (I) Ethoxide, also known as Thallium Ethylate, is a chemical compound with the formula Tl(OC2H5). It is a cloudy, dense liquid that is sensitive to moisture. Thallium (I) Ethoxide is a versatile reagent in organic synthesis, known for its unique properties and applications in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
Thallium (I) Ethoxide is used as a catalyst in Suzuki cross-coupling reactions, which are widely employed in the synthesis of complex organic molecules, including pharmaceutical compounds. This application is crucial for the development of new drugs and the modification of existing ones to improve their efficacy and safety.
Used in Chemical Synthesis:
Thallium (I) Ethoxide is used as a reducing agent in conjunction with hydrochloric acid (HCl) to reduce a variety of functional groups. This property makes it a valuable tool in organic synthesis, allowing chemists to perform selective reductions and functional group transformations.
Used in Stereoselective Allylation:
Thallium (I) Ethoxide is employed in the stereoselective allylation of carbonyl compounds, which is an essential process in the synthesis of complex organic molecules with specific stereochemistry. This application is particularly important in the development of enantiomerically pure compounds, which are often required for pharmaceutical and agrochemical applications.
Used in Directed Aldol Reactions:
Thallium (I) Ethoxide is used in the in situ generation of tin enolates for directed aldol reactions. Aldol reactions are fundamental in organic chemistry, as they allow the formation of new carbon-carbon bonds and the creation of complex molecular structures. The use of Thallium (I) Ethoxide in this process enhances the selectivity and efficiency of the reaction, leading to the desired products with minimal side reactions.
Safety Profile
Poison by ingestion.
When heated to decomposition it emits
toxic fumes of T1. See also THALLIUM
COMPOUNDS
Check Digit Verification of cas no
The CAS Registry Mumber 20398-06-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,3,9 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 20398-06:
(7*2)+(6*0)+(5*3)+(4*9)+(3*8)+(2*0)+(1*6)=95
95 % 10 = 5
So 20398-06-5 is a valid CAS Registry Number.
InChI:InChI=1/C2H6O.Tl/c1-2-3;/h3H,2H2,1H3;
20398-06-5Relevant articles and documents
Preparation of cyclic ketones
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, (2008/06/13)
Cyclic ketones, notably cyclopentanone and 2,2-dimethylcyclopentanone, are simply, economically and efficiently prepared, even on an industrial scale, by decarboxylating/cyclizing a dicarboxylic acid, in liquid phase, in the presence of a catalytically effective amount of a metal or compound thereof selected from among boron, aluminum, gallium, indium, thallium, tin, antimony, bismuth, molybdenum, rubidium, cesium and vanadium.
