2141-17-5

Basic information

• Product Name: 4-Hydroxy-Testosterone
• Synonyms: (8R,9S,10R,13S,14S,17S)-4,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one;4,17 beta-dihydroxy-4-androstene-3-one;(17β)-4,17-Dihydroxyandrost-4-en-3-one
• CAS NO: 2141-17-5
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.423820
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids
• Mol File: 2141-17-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 222-223 °C
• Boiling Point: 476.3 °C at 760 mmHg
• Flash Point: 255.9 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 4.52E-11mmHg at 25°C
• Refractive Index: 1.578
• PKA: 9.32±0.70(Predicted)
• CAS DataBase Reference: 4-Hydroxy-Testosterone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-Testosterone(2141-17-5)
• EPA Substance Registry System: 4-Hydroxy-Testosterone(2141-17-5)

Safety Data

• Hazardous Substances Data: 2141-17-5(Hazardous Substances Data)

Usage

Description

4-Hydroxy-Testosterone is a metabolite of the aromatase inhibitor Formestane (F692250) and is classified as an anabolic steroid. It is a white solid with no therapeutic indication and is considered a controlled substance. The presence of 4-Hydroxy-Testosterone in urine can be utilized as a biomarker for detecting steroid misuse.

Uses

Used in Anti-Doping Applications:
4-Hydroxy-Testosterone is used as a biomarker for steroid misuse, particularly in the field of sports and athletics. Its detection in urine samples helps in identifying the abuse of anabolic steroids, ensuring fair competition and adherence to anti-doping regulations.
Used in Pharmaceutical Research:
4-Hydroxy-Testosterone, being a metabolite of the aromatase inhibitor Formestane, is used in pharmaceutical research for studying the effects and mechanisms of action of such inhibitors. This aids in the development of potential treatments for conditions related to hormonal imbalances or steroid misuse.
Used in Toxicology and Forensic Analysis:
In the fields of toxicology and forensic analysis, 4-Hydroxy-Testosterone is utilized as a marker for anabolic steroid abuse. Its detection in biological samples can provide valuable information in cases involving substance abuse or illicit drug use, assisting in legal proceedings and investigations.

InChI:InChI=1/C19H28O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,16,21-22H,3-10H2,1-2H3/t11-,12-,13-,16-,18+,19-/m0/s1

Upstream product

• 13452-06-7 4-hydroxy-3-oxo-4-androsten-17β-yl acetate 
• 1045-69-8 testosterone acetate 
• 855-19-6 clostebol acetate 
• 58-22-0 testosterone 
• 571-22-2 5β-androstan-17β-ol-3-one 
• 51154-10-0 17β-hydroxy-4ξ,5-oxido-5ξ-androstan-3-one 
• 7637-07-2 boron trifluoride 
• 2189-83-5 17β-hydroxy-4β,5-epoxy-5β-androstan-3-one 
• 71-43-2 benzene 
• 17597-25-0 17β-hydroxy-4α,5-epoxy-5α-androstan-3-one 
• 4721-70-4 4,17β-dihydroxy-4,6-androstadien-3-one 
• 2189-83-5 (10R,13S,17S)-17-Hydroxy-10,13-dimethyl-tetradecahydro-20-oxa-cyclopropa[4,5]cyclopenta[a]phenanthren-3-one 

Downstream Products

• 2562-44-9 17β-(3-cyclopentyl-propionyloxy)-4-hydroxy-androst-4-en-3-one 
• 59599-19-8 5α-androstane-3β,4β,17β-triol 
• 1290088-67-3 17β-acetoxy-4-oxo-5α-androstano[2,3-d]isoxazole 
• 1290088-68-4 2-cyano-3,17β-dihydroxy-5α-androst-2-en-4-one 
• 171063-41-5 17β-hydroxy-4-oxo-5α-androstano[2,3-d]pyrazole 
• 1202643-15-9 C₂₈H₅₂O₃Si₃ 
• 38553-32-1 (8R,9S,10R,13S,14S,17S)-17-(Cyclopent-1-enyloxy)-4-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 112573-62-3 3,4-dioximino-5ξ-androstan-17β-ol 
• 103270-11-7 4,17β-bis-phenylacetoxy-androst-4-en-3-one 
• 104921-27-9 17β-hydroxy-5β,17α-pregn-20-yno<3,4-c>-1',2',5'-oxadiazole 
• 104921-26-8 17β-hydroxy-5α,17α-pregn-20-yno<3,4-c>-1',2',5'-oxadiazole 
• 112517-11-0 5α-androstano<3,4-c>-1',2',5'-oxadiazol-17β-ol 
• 112517-10-9 5β-androstano<3,4-c>-1',2',5'-oxadiazol-17β-ol 
• 104921-30-4 5α-androstano<3,4-c>-1',2',5'-oxadiazol-17-one 

Relevant articles and documents

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C-19 steroids for cosmetic uses

The present invention relates to novel uses of C-19 steroid compounds, in particular C-19 steroids having an androsten-17-(OR 4 )-3-one structure for cosmetic and further uses, wherein R 4 is hydrogen or an unsubstituted or substituted alkyl, aryl, acyl or any group leading to hydroxyl upon biological metabolization or chemical deprotection. The present invention particularly relates to selected C-19 steroids displaying properties of high binding affinity to androgen receptor to block dihydotestosterone from binding, while at the same time providing anabolic effects, which is useful for certain applications, particularly for influencing or controlling problems of the skin and its skin-associated body structures like cellulite, wrinkles, adipose fat tissues, hair follikles or hair growth; for influencing or controlling gland function and activity such as the sebaceous gland and other glands affecting the skin and/or perspiration. The present invention also describes a composition comprising a combination of such a compound and dimethyl isosorbide.

Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers

The present invention relates to novel uses of 4,17β-dihydroxyandrost-4-ene-3-one (hereinafter 4-hydroxytestosterone), to a process for their preparation, to pharmaceutical compositions containing them, and to the use of said compounds for the prophylaxis and/or treatment of hormone-dependent or hormone receptor regulated cancers in mammals.