21780-68-7

Basic information

• Product Name: N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea
• Synonyms: 1-(p-Methoxyphenyl)-3-(2-pyridyl)thiourea;N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea;1-(4-METHOXYPHENYL)-3-(2-PYRIDYL)-2-THIOUREA
• CAS NO: 21780-68-7
• Molecular Formula: C₁₃H₁₃N₃OS
• Molecular Weight: 259.3268
• Mol File: 21780-68-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 145 °C
• Boiling Point: 407.4°Cat760mmHg
• Flash Point: 200.2°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 7.57E-07mmHg at 25°C
• Refractive Index: 1.721
• PKA: 11.27±0.70(Predicted)
• CAS DataBase Reference: N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea(21780-68-7)
• EPA Substance Registry System: N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea(21780-68-7)

Safety Data

• Hazardous Substances Data: 21780-68-7(Hazardous Substances Data)

Usage

Description

N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea is a chemical compound characterized by its molecular formula C13H12N4OS. It is a white to off-white solid that exhibits a wide range of industrial applications, particularly in the synthesis of pharmaceuticals and agrochemicals. Additionally, it serves as a corrosion inhibitor in the petroleum industry. N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea has also garnered interest for its potential biological activities, such as its anti-inflammatory properties and effects on various biological pathways. However, it is crucial to handle N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea with care due to its potential hazards to human health and the environment.

Uses

Used in Pharmaceutical and Agrochemical Industries:
N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows it to be a key component in the development of new drugs and agricultural products.
Used in Petroleum Industry:
In the petroleum industry, N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea is employed as a corrosion inhibitor. Its application helps to prevent the corrosion of pipelines and storage tanks, thereby extending their service life and reducing maintenance costs.
Used in Biological Research:
N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea has been studied for its potential biological activities, such as its role as an anti-inflammatory agent. This research is crucial for understanding its effects on various biological pathways and its potential use in the development of new therapeutic agents.
Used in Environmental Protection:
Due to its potential hazards to human health and the environment, N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea is also used in the development of strategies for environmental protection and safety measures to minimize its impact on ecosystems and human populations.

InChI:InChI=1/C13H13N3OS/c1-17-11-7-5-10(6-8-11)15-13(18)16-12-4-2-3-9-14-12/h2-9H,1H3,(H2,14,15,16,18)

Upstream product

• 504-29-0 2-aminopyridine 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Downstream Products

• 79834-34-7 3-Amino-5-p-methoxyphenylimino-4-(2-pyridyl)-4,5-dihydro-1,2,4-thiadiazole 
• 78755-05-2 1-(4-methoxyphenyl)-3-(2-pyridyl)thiobarbiturate 
• 69437-82-7 2-(4-Anisyl)-3-(2'-pyridyl)-thiazolidin-4-on 

Relevant articles and documents

Nickle Catalysis Enables Access to Thiazolidines from Thioureas via Oxidative Double Isocyanide Insertion Reactions

An efficient synthesis of thiazolidine-2,4,5-triimine derivatives was developed via Ni-catalyzed oxidative double isocyanide insertion to thioureas under air conditions, in which thioureas play three roles as a substrate, a ligand, and overcoming isocyanide polymerization. The reaction is featured by employing a low-cost and low loading Ni(acac)2 catalyst, without any additives, and high atom economy. This is the first example to directly apply a Ni(II) catalyst in oxidative double isocyanide insertion reactions.

Corrosion-protective properties of 1-phenacylmethyl-2- arylcarbamido(arylthiocarbamido)pyridinium bromides

Inhibiting effect of 1-phenacylmethylpyridinium bromides containing urea or thiourea substituents in the pyridinium ring on steel and zinc corrosion in sulfuric acid solutions was studied.

Synthesis and antibacterial activity of pyridyl thioureas and arylthiosemicarbazones

[N-(2-pyridyl)-N'-(4-(un) substituted] thioureas and (substitutedaryl)thiosemicarbazones were synthesised and evaluated for their antibacterial activity. All aryl thiosemicarbazones showed good activity against Aeromonas hydrophilia and Salmonella typhimuriurn. But none of the pyridyl thioureas showed any prominent activity against tested bacteria.