21920-79-6

Basic information

• Product Name: 6-(azepan-1-yl)hexan-1-amine
• Synonyms: 6-(azepan-1-yl)hexan-1-amine
• CAS NO: 21920-79-6
• Molecular Weight: 198.352
• Mol File: 21920-79-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-(azepan-1-yl)hexan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(azepan-1-yl)hexan-1-amine(21920-79-6)
• EPA Substance Registry System: 6-(azepan-1-yl)hexan-1-amine(21920-79-6)

Safety Data

• Hazardous Substances Data: 21920-79-6(Hazardous Substances Data)

Upstream product

• 124-04-9 Adipic acid 
• 105-60-2 caprolactam 
• 629-11-8 1,6-hexanediol 
• 111-49-9 hexamethylene imine 
• 124-09-4 1,6-Hexanediamine 
• 4048-33-3 6-amino-1-hexanol 

Relevant articles and documents

One-pot reductive amination of carboxylic acids: a sustainable method for primary amine synthesis

The reductive amination of carboxylic acids is a very green, efficient and sustainable method for the production of (bio-based) amines. However, with current technology, this reaction requires two to three reaction steps. Here, we report the first (heterogeneous) catalytic system for the one-pot reductive amination of carboxylic acids to amines, with solely H2 and NH3 as the reactants. This reaction can be performed with relatively cheap ruthenium-tungsten bimetallic catalysts in the green and benign solvent cyclopentyl methyl ether (CPME). Selectivities of up to 99% for the primary amine could be achieved at high conversions. Additionally, the catalyst is recyclable and tolerant for common impurities such as water and cations (e.g. sodium carboxylate).

Reductive amination of 1,6-hexanediol with Ru/Al2O3 catalyst in supercritical ammonia

Hexamethylenediamine (HMDA) is an important reagent for the synthesis of Nylon-6,6, and it is usually produced by the hydrogenation of adiponitrile using a toxic reagent of hydrocyanic acid. Herein, we developed an environmental friendly route to produce HMDA via catalytic reductive amination of 1,6-hexanediol (HDO) in the presence of hydrogen. The activities of several heterogeneous metal catalysts such as supported Ni, Co, Ru, Pt, Pd catalysts were screened for the present reaction in supercritical ammonia without any additives. Among the catalysts examined, Ru/Al2O3 presented a high catalytic activity and highest selectivity for the desired product of HMDA. The high performance of Ru/Al2O3 was discussed based on the Ru dispersion and the surface properties like the acid-basicity. In addition, the reaction parameters such as reaction temperature, time, H2 and NH3 pressure were examined, and the reaction processes were discussed in detail.