220772-52-1

Basic information

• Product Name: 4-Piperidinone, 1-[(3,4-dichlorophenyl)methyl]-
• CAS NO: 220772-52-1
• Molecular Formula: C12H13Cl2NO
• Molecular Weight: 258.147
• Mol File: 220772-52-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-Piperidinone, 1-[(3,4-dichlorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinone, 1-[(3,4-dichlorophenyl)methyl]-(220772-52-1)
• EPA Substance Registry System: 4-Piperidinone, 1-[(3,4-dichlorophenyl)methyl]-(220772-52-1)

Safety Data

• Hazardous Substances Data: 220772-52-1(Hazardous Substances Data)

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 18880-04-1 3,4-dichlorobenzyl bromide 
• 41661-47-6 piperidin-4-one 
• 102-47-6 3,4-Dichlorophenylmethyl chloride 

Downstream Products

• 220772-53-2 ethyl [1-(3,4-dichlorobenzyl)piperidin-4-ylidene]acetate 
• 328083-67-6 N'-[1-(3,4-dichlorobenzyl)-4-piperidinyl]-2-[4-(trifluoromethoxy)phenoxy]acetohydrazide 
• 328084-02-2 (2-{[1-(3,4-Dichloro-benzyl)-piperidin-4-yl]-methyl-amino}-ethyl)-carbamic acid tert-butyl ester 
• 328083-81-4 tert-butyl 2-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}ethylcarbamate 
• 328084-04-4 1-(3,4-dichlorobenzyl)-4-(methylamino)piperidine 
• 220772-54-3 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropanol 
• 220772-55-4 1-[1-(3,4-dichlorobenzyl)piperidin-4-yl]-3-methyl-2-butanone 
• 220772-56-5 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine 
• 185434-43-9 ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate 

Relevant articles and documents

Substituted piperidine compounds useful as modulators of chemokine receptor activity

The invention provides compounds of formula (I) wherein R1, R2, R3, R6, Z, Q, m, n, X1, X2, X3, X4 and T are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions

Design and synthesis of novel CCR3 antagonists

As part of our investigation into the development of potent CCR3 antagonists, a series of piperidine analogues was designed and prepared. Exploration of the piperidine core examined both the basicity and the location of a nitrogen, as well as conformational variants. The bicyclo-piperidine 24c was found to be the most potent inhibitor of CCR3 with an IC50 of 0.0082 μM in the binding assay and 0.0024 μM in the chemotaxis assay.

Cyclic amine derivatives- CCR-3 receptor antagonists

This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.