221018-80-0Relevant articles and documents
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke
Grauert, Matthias,Bechtel, Wolf D.,Weiser, Thomas,Stransky, Werner,Nar, Herbert,Carter, Adrian J.
, p. 3755 - 3764 (2007/10/03)
We have synthesized a series of 6,7-benzomorphan derivatives and determined their ability to bind to voltage-dependent sodium channels. We have also compared the functional consequences of this blockade in vitro and in vivo. The ability of the compounds t