221381-89-1

Basic information

• Product Name: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester
• Synonyms: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester;methyl 4-(2-oxopyrrolidin-1-yl)benzoate;4-(2-ketopyrrolidin-1-yl)benzoic acid methyl ester;4-(2-oxo-1-pyrrolidinyl)benzoic acid methyl ester;4-(2-Oxo-pyrrolidin-1-yl)-benzoic acid methyl ester;BAS 00358368;CBDivE_015964;ST5449463
• CAS NO: 221381-89-1
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.23652
• Mol File: 221381-89-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 118-120 °C(Solv: chloroform (67-66-3); ethyl ether (60-29-7))
• Boiling Point: 447.6±28.0 °C(Predicted)
• Appearance: /
• Density: 1.229±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -2.06±0.20(Predicted)
• CAS DataBase Reference: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester(221381-89-1)
• EPA Substance Registry System: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester(221381-89-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 221381-89-1(Hazardous Substances Data)

Upstream product

• 616-45-5 2-pyrrolidinon 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 10338-58-6 N-(4-[methyl 4-benzoxycarbonyl])piperidine 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 36151-44-7 4-(2-oxopyrrolidin-1-yl)benzoic acid 
• 68737-65-5 (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane 
• 150-13-0 4-amino-benzoic acid 
• 619-44-3 methyl 4-iodobenzoate 
• 67-56-1 methanol 

Downstream Products

• 36152-29-1 1-(4-(chloromethyl)phenyl)pyrrolidin-2-one 
• 1204311-22-7 1-(4-(hydroxymethyl)phenyl)pyrrolidin-2-one 
• 221381-92-6 1-<4-methoxycarbonyl-2-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl>pyrrolidin-2-one 
• 234110-57-7 1-{2-{[(Amino)(imino)methyl]amino}-4-carboxyphenyl}pyrrolidin-2-one 
• 221382-11-2 1-<4-methoxycarbonyl-2-(3-pentylamino)phenyl>pyrrolidin-2-one 
• 221381-91-5 1-(4-methoxycarbonyl-2-aminophenyl)pyrrolidin-2-one 
• 36151-44-7 4-(2-oxopyrrolidin-1-yl)benzoic acid 
• 221381-90-4 1-(4-methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one 

Relevant articles and documents

Ring size changes in the development of class I HDAC inhibitors

Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.

THERAPEUTIC INHIBITORY COMPOUNDS

The invention provides compounds of Formula I and Formula II: A-B-C-D-E-F-G-J (I) C-D-E-F-G-J (II) wherein A, B, C, D, E, F, G, and J have any of the values defined in the specification, and salts thereof. The compounds are useful for inhibiting plasma kallikrein, and for treating a disease or condition in an animal where inhibition of plasma kallikrein is indicated.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.