22304-66-1

Basic information

• Product Name: 1-(5-ACETYL-2,4-DIHYDROXY-3-METHYLPHENYL)ETHAN-1-ONE
• Synonyms: 1-(5-ACETYL-2,4-DIHYDROXY-3-METHYLPHENYL)ETHAN-1-ONE
• CAS NO: 22304-66-1
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.21
• Mol File: 22304-66-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 139–142°C
• Appearance: /
• CAS DataBase Reference: 1-(5-ACETYL-2,4-DIHYDROXY-3-METHYLPHENYL)ETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-ACETYL-2,4-DIHYDROXY-3-METHYLPHENYL)ETHAN-1-ONE(22304-66-1)
• EPA Substance Registry System: 1-(5-ACETYL-2,4-DIHYDROXY-3-METHYLPHENYL)ETHAN-1-ONE(22304-66-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 22304-66-1(Hazardous Substances Data)

Usage

Preparation

Preparation by Fries rearrangement of 2,6-diacetoxytoluene with aluminium chloride in nitrobenzene, ? at 75° for 3 h, under nitrogen (63%) ; ? at 67° for 4 h (58%).

Upstream product

• 608-25-3 2-methylbenzene-1,3-diol 
• 108-24-7 acetic anhydride 
• 35236-42-1 2-methyl-1,3-phenylene diacetate 

Downstream Products

• 107167-44-2 5-cinnamoyl-2,4-dihydroxy-3-methylchalcone 
• 107167-52-2 3-(3,4-Dimethoxy-phenyl)-1-{5-[3-(3,4-dimethoxy-phenyl)-propionyl]-2,4-dihydroxy-3-methyl-phenyl}-propan-1-one 
• 107167-50-0 1-{2,4-Dihydroxy-5-[3-(4-methoxy-phenyl)-propionyl]-3-methyl-phenyl}-3-(4-methoxy-phenyl)-propan-1-one 
• 107167-51-1 1-[2,4-Dihydroxy-3-methyl-5-(3-p-tolyl-propionyl)-phenyl]-3-p-tolyl-propan-1-one 
• 107167-45-3 5-(α',β'-dihydrocinnamoyl)-2,4-dihydroxy-3-methyl-α,β-dihydrochalcone 
• 107167-48-6 (E)-3-(3,4-Dimethoxy-phenyl)-1-{5-[(E)-3-(3,4-dimethoxy-phenyl)-acryloyl]-2,4-dihydroxy-3-methyl-phenyl}-propenone 
• 107167-46-4 (E)-1-{2,4-Dihydroxy-5-[(E)-3-(4-methoxy-phenyl)-acryloyl]-3-methyl-phenyl}-3-(4-methoxy-phenyl)-propenone 
• 107167-47-5 (E)-1-[2,4-Dihydroxy-3-methyl-5-((E)-3-p-tolyl-acryloyl)-phenyl]-3-p-tolyl-propenone 

Relevant articles and documents

Benzodipyrazoles: Non-Xanthine Adenosine Antagonists

3,5-Dimethylbenzodipyrazoles, optionally substituted in the 1-, 7-, and 8-positions, were synthesized from resorcinols.These compounds display affinity for adenosine A1 (rat brain) and A2 (human platelet) receptors.In addition, these compounds reverse contractions of guinea pig tracheal cylindrical segments induced by potassium chloride, histamine, acetylcholine, and 5-hydroxytryptamine, as well as reverse bronchospasm induced by aerosolized histamine in the conscious guinea pig.