225517-50-0

Basic information

• Product Name: (R)-3-(4-Benzyloxy-phenyl)-3-[benzyl-((S)-1-phenyl-ethyl)-amino]-propionic acid methyl ester
• Synonyms: (R)-3-(4-Benzyloxy-phenyl)-3-[benzyl-((S)-1-phenyl-ethyl)-amino]-propionic acid methyl ester
• CAS NO: 225517-50-0
• Molecular Weight: 479.619
• Mol File: 225517-50-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3-(4-Benzyloxy-phenyl)-3-[benzyl-((S)-1-phenyl-ethyl)-amino]-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(4-Benzyloxy-phenyl)-3-[benzyl-((S)-1-phenyl-ethyl)-amino]-propionic acid methyl ester(225517-50-0)
• EPA Substance Registry System: (R)-3-(4-Benzyloxy-phenyl)-3-[benzyl-((S)-1-phenyl-ethyl)-amino]-propionic acid methyl ester(225517-50-0)

Safety Data

• Hazardous Substances Data: 225517-50-0(Hazardous Substances Data)

Upstream product

• 17480-69-2 (S)-N-benzyl-1-phenylethylamine 
• 84184-51-0 (E)-methyl 3-(4-(benzyloxy)phenyl)acrylate 
• 6373-46-2 p-benzyloxyaniline 

Relevant articles and documents

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

A series of substituted N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl- and (L)-azetidyl-beta-biaryl beta-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimizing potency. Oral bioavailability was variable and may be a result of binding to circulating plasma proteins.