234111-08-1

Basic information

• Product Name: 2-Bromo-6-iodopyridine
• Synonyms: 2-BROMO-6-IODOPYRIDINE;6-BROMO-2-IODOPYRIDINE;2-Bromo-6-iodopyridine 95+%;2-BroMo-6-iodopyridne;Pyridine, 2-broMo-6-iodo-;2-Bromo-6-Iodopyridine,97%
• CAS NO: 234111-08-1
• Molecular Formula: C₅H₃BrIN
• Molecular Weight: 283.89
• EINECS: -0
• Product Categories: Pyridine series;Halides;Pyridines;Heterocycle;alkyl bromide| alkyl Iodine
• Mol File: 234111-08-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 139-143℃
• Boiling Point: 286.7 °C at 760 mmHg
• Flash Point: 127.2 °C
• Appearance: /
• Density: 2.347g/cm³
• Vapor Pressure: 0.00448mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-Bromo-6-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-iodopyridine(234111-08-1)
• EPA Substance Registry System: 2-Bromo-6-iodopyridine(234111-08-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• Hazardous Substances Data: 234111-08-1(Hazardous Substances Data)

Usage

Description

2-Bromo-6-iodopyridine is an organic compound characterized by the presence of bromine and iodine atoms at the 2nd and 6th positions of the pyridine ring, respectively. It is a versatile intermediate in the synthesis of various pharmaceuticals and chemical compounds due to its unique structural features and reactivity.

Uses

Used in Pharmaceutical Synthesis:
2-Bromo-6-iodopyridine is used as a key intermediate in the synthesis of 6-trifluoromethyl-2-pyridinecarboxylic acid, which is an important compound in the development of pharmaceuticals. The trifluoromethylating displacement of iodine in 2-bromo-6-iodopyridine allows for the formation of 2-bromo-6-(trifluoromethyl)pyridine, which can then be further converted to the desired carboxylic acid.
In the context of pharmaceutical applications, 2-bromo-6-iodopyridine serves as a building block for creating novel compounds with potential therapeutic properties. Its unique substitution pattern and reactivity make it a valuable starting material for the development of new drugs targeting various diseases and conditions.

InChI:InChI=1/C5H3BrIN/c6-4-2-1-3-5(7)8-4/h1-3H

Upstream product

• 109-04-6 2-bromo-pyridine 
• 626-05-1 2,6-Dibromopyridine 
• 7553-56-2 iodine 
• 19798-81-3 2-Amino-6-bromopyridine 

Downstream Products

• 193344-39-7 2-bromo-6-(4-methoxyphenyl)pyridine 
• 193344-34-2 6'-bromo-5-(3-methoxy-phenyl)-[2,2']bipyridinyl 
• 189278-27-1 2-bromo-6-(trifluoromethyl)pyridine 
• 537676-72-5 2-(3-iodo-phenylethynyl)-6-trimethylsilanylethynyl-pyridine 
• 537676-73-6 3-iodo-5-(6-trimethylsilanylethynyl-pyridin-2-ylethynyl)-benzoic acid methyl ester 
• 669063-85-8 C₃₃H₂₃IN₂Si 
• 669063-86-9 C₃₇H₂₇IN₂O₄Si 
• 1223104-42-4 C₄₇H₅₂BrNO 
• 1383847-06-0 (R)-5-(3-Amino-4-fluoro-1-(3-(6-(prop-1-ynyl)pyridin-2-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one 
• 1401527-42-1 (6-bromopyridin-2-yl)(4’-methoxyphenyl)iodonium tosylate 

Relevant articles and documents

Site-selective monotitanation of dialkynylpyridines and its application for preparation of highly fluorescent π-conjugated oligomers

(Chemical Equation Presented) Reaction of Ti(O-i-Pr)4/2i-PrMgCl reagent with 2,n-bis[(trimethylsilyl)ethynyl]pyridines, where n is 3, 4, 5, and 6, or with 3,4-bis[(trimethylsilyl)-ethynyl]pyridines, proceeded with excellent site-selectivity to afford the corresponding monotitanated complex. Synthetic application of the reaction was demonstrated by an efficient preparation of π-conjugated oligomers having pyridine and enyne units alternately, which possess intense blue fluorescence emission.

Deprotonative metalation of chloro- and bromopyridines using amido-based bimetallic species and regioselectivity-computed CH acidity relationships

A series of chloro- and bromopyridines have been deprotometalated by using a range of 2,2,6,6-tetramethylpiperidino-based mixed lithium-metal combinations. Whereas lithium-zinc and lithium-cadmium bases afforded different mono- and diiodides after subsequent interception with iodine, complete regioselectivities were observed with the corresponding lithium-copper combination, as demonstrated by subsequent trapping with benzoyl chlorides. The obtained selectivities have been discussed in light of the CH acidities of the substrates, determined both in the gas phase and as a solution in THF by using the DFT B3LYP method.

Shape-persistent cyclyne-type azamacrocycles: Synthesis, unusual light-emitting characteristics, and specific recognition of the Sb(V) ion

Simple members of arene-azaarenecyclynes as a novel family of geometrically-controlled and shape-persistent azamacrocycles have been synthesized. Noteworthy is the specific recognition function for Sb(V). The synthesized azamacrocycles, in particular the