2403-54-5

Basic information

• Product Name: 2-(4-Chlorophenyl)-1,3-dioxolane
• Synonyms: 2-(4-chlorophenyl)-1,3-dioxolane;1-(1,3-Dioxolane-2-yl)-4-chlorobenzene;2-(p-Chlorophenyl)-1,3-dioxolane;4-Chlorobenzaldehyde ethylene acetal;1,3-Dioxolane, 2-(4-chlorophenyl)-;1,3-Dioxolane, 2-(p-chlorophenyl)-;Nsc202824
• CAS NO: 2403-54-5
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• Mol File: 2403-54-5.mol
• Article Data: 55

Chemical Properties

• Boiling Point: 267.8 °C at 760 mmHg
• Flash Point: 112.6 °C
• Appearance: /
• Density: 1.256 g/cm³
• Vapor Pressure: 0.0132mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 2-(4-Chlorophenyl)-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-1,3-dioxolane(2403-54-5)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-1,3-dioxolane(2403-54-5)

Safety Data

• Hazardous Substances Data: 2403-54-5(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-1,3-dioxolane, also known as Dioxolane, is a chemical compound with the molecular formula C8H7ClO2. It is a colorless liquid with a sweet odor, commonly used as a solvent and in the manufacturing of pharmaceuticals and agrochemicals. Dioxolane is also used as an intermediate in the synthesis of other organic compounds. It is important to handle this chemical with care as it may cause skin and eye irritation upon contact. Furthermore, it is important to take proper safety precautions when working with this compound, as prolonged or repeated exposure may lead to harmful effects on health.

InChI:InChI=1/C9H9ClO2/c10-8-3-1-7(2-4-8)9-11-5-6-12-9/h1-4,9H,5-6H2

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 122-51-0 orthoformic acid triethyl ester 
• 7381-30-8 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane 
• 107-07-3 2-chloro-ethanol 
• 1200-15-3 2-(4-chloro-benzyloxy)-ethanol 
• 107-21-1 ethylene glycol 
• 22391-05-5 2-(4-chlorophenyl)-1,3-oxathiolane 
• 265134-89-2 1-(1,3-dioxolan-2-yl)-1H-1,2,3-benzotriazole 
• 111-90-0 ethoxyethoxyethanol 
• 39184-66-2 (4-chlorophenyl)chlorodiazirine 

Downstream Products

• 57479-23-9 8-(4-chlorophenyl)quinoline 
• 144689-63-4 olmesartan medoxomil 
• 144690-92-6 trityl olmesartan medoxomil 
• 1114761-92-0 lithium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate 
• 144690-33-5 ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate 
• 124750-51-2 N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole 
• 154709-18-9 4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl 
• 155983-56-5 5-<2-(4'-formylbiphenylyl)>-2-(triphenylmethyl)-2H-tetrazole 
• 128654-20-6 1-benzoyloxy 2-(4-chlorobenzoyloxy)ethane 
• 57847-59-3 1,2-bis-(4-chloro-benzoyloxy)-ethane 
• 4750-61-2 N-(p-chlorobenzyl)aniline 
• 32377-36-9 anilino(4-chlorophenyl)acetonitrile 
• 1236-90-4 2-(4-chlorophenyl)-4-phenylquinoline 
• 1450806-18-4 2-(1-(4-chlorophenyl)-2,2,2-trifluoroethyl)-1,3-dioxolane 

Relevant articles and documents

Application of poly(Vinylbenzyltrimethylammonium tribromide) resin as an efficient polymeric catalyst in the acetalization and diacetylation of benzaldehydes

The applications of a new supported tribromide reagent (poly(vinylbenzyltrimethylammonium tribromide) resin) were reported. This supported tribromide resin was used as a catalyst in the acetalization and diacetylation of benzaldehydes under mild conditions with high efficiency. The effects of solvents, and amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, most of acetal and 1,1-diacetates of benzaldehydes were selectively obtained in excellent yields.

Robust acidic pseudo-ionic liquid catalyst with self-separation ability for esterification and acetalization

The novel acidic pseudo-ionic liquid catalyst with self-separation ability has been synthesized through the quaternization of triphenylphosphine and the acidification with silicotungstic acid. The pseudo-IL showed high activities for the esterification with average conversions over 90%. The pseudo-IL showed even higher activities for acetalization than traditional sulfuric acid. The homogeneous catalytic process benefited the mass transfer efficiency. The pseudo-IL separated from the reaction mixture automatically after reactions, which was superior to other IL catalysts. The high catalytic activities, easy reusability and high stability were the key properties of the novel catalyst, which hold great potential for green chemical processes.

Utilization of 1,3-Dioxolanes in the Synthesis of α-branched Alkyl and Aryl 9-[2-(Phosphonomethoxy)Ethyl]Purines and Study of the Influence of α-branched Substitution for Potential Biological Activity

Syntheses of α-branched alkyl and aryl substituted 9-[2-(phosphonomethoxy)ethyl]purines from substituted 1,3-dioxolanes have been developed. Key synthetic precursors, α-substituted dialkyl [(2-hydroxyethoxy)methyl]phosphonates were prepared via Lewis acid mediated cleavage of 1,3-dioxolanes followed by reaction with dialkyl or trialkyl phosphites. The best preparative yields were achieved under conditions utilizing tin tetrachloride as Lewis acid and triisopropyl phosphite. Attachment of purine bases to dialkyl [(2-hydroxyethoxy)methyl]phosphonates was performed by Mitsunobu reaction. Final α-branched 9-[2-(phosphonomethoxy)ethyl]purines were tested for antiviral, cytostatic and antiparasitic activity, the latter one determined as inhibitory activity towards Plasmodium falciparum enzyme hypoxanthine-guanine-xanthine phosphoribosyltransfesase. In most cases biological activity was only marginal.