2403-58-9

Basic information

• Product Name: p-(diethoxymethyl)anisole
• Synonyms: p-(diethoxymethyl)anisole;Benzene, 1-(diethoxymethyl)-4-methoxy-;4-(Diethoxymethyl)anisole;1-(Diethoxymethyl)-4-methoxybenzene;Nsc20033
• CAS NO: 2403-58-9
• Molecular Formula: C₁₂H₁₈O₃
• Molecular Weight: 210.26952
• EINECS: 219-288-6
• Mol File: 2403-58-9.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 103-104°C/3.5mm
• Flash Point: 103-104°C/3.5mm
• Appearance: /
• Density: 1.06
• Refractive Index: 1.4920
• CAS DataBase Reference: p-(diethoxymethyl)anisole(CAS DataBase Reference)
• NIST Chemistry Reference: p-(diethoxymethyl)anisole(2403-58-9)
• EPA Substance Registry System: p-(diethoxymethyl)anisole(2403-58-9)

Safety Data

• Hazardous Substances Data: 2403-58-9(Hazardous Substances Data)

Usage

Description

p-(diethoxymethyl)anisole is a colorless organic chemical compound with a molecular formula of C12H18O3, derived from anisole, a naturally occurring substance found in certain plant species. It is characterized by its sweet, floral odor and is commonly used as a fragrance and flavor ingredient in various cosmetic and personal care products.

Uses

Used in Cosmetic and Personal Care Products:
p-(diethoxymethyl)anisole is used as a fragrance and flavor ingredient for its sweet, floral scent, enhancing the sensory experience of perfumes and scented products.
Used in Organic Chemistry:
p-(diethoxymethyl)anisole serves as a solvent and a reagent in various organic chemistry reactions, facilitating the synthesis and processing of other chemical compounds.
Used in Flavor Industry:
p-(diethoxymethyl)anisole is used as a flavoring agent to impart a pleasant taste and aroma to food and beverage products, enhancing their overall appeal to consumers.
Safety Precautions:
It is important to handle p-(diethoxymethyl)anisole with caution and follow proper safety protocols, as it can be harmful if ingested or inhaled and may cause skin and eye irritation.

InChI:InChI=1/C12H18O3/c1-4-14-12(15-5-2)10-6-8-11(13-3)9-7-10/h6-9,12H,4-5H2,1-3H3

Upstream product

• 64-17-5 ethanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 122-51-0 orthoformic acid triethyl ester 
• 2299-73-2 N,N-bis(4-methoxybenzylidene)hydrazine 
• 88920-25-6 ethoxy-p-methoxyphenylacetic acid 
• 873376-62-6 triethoxyantimony 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 104-46-1 anethole 
• 104-94-9 4-methoxy-aniline 
• 105-13-5 4-Methoxybenzyl alcohol 
• 998-30-1 Triethoxysilane 
• 36141-66-9 ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 16694-46-5 ethyl formimidate hydrochloride 

Downstream Products

• 21191-28-6 N,N'-(4-methoxy-benzylidene)-bis-carbamic acid diethyl ester 
• 82343-41-7 4-methoxybenzaldehyde di-n-butyl acetal 
• 90875-17-5 Aethoxy-<4-methoxy-phenyl>-methylbromid 
• 109976-91-2 5-[ethoxy(4-methoxyphenyl)methyl]quinolin-6-ol 
• 105192-47-0 α,α-bis(8-hydroxyquinolin-7-yl)-4-methoxytoluene 
• 82724-67-2 1,1,5-Triethoxy-5-(4-methoxyphenyl)-2-pentene 
• 74586-85-9 1,1,5,9-Tetraethoxy-9-(4-methoxyphenyl)-2,6-nonadiene 
• 23837-14-1 1-(Bis-butylsulfanyl-methyl)-4-methoxy-benzene 
• 97056-50-3 1,1,5-triethoxy-5-(4-methoxyphenyl)-3-methyl-2-pentene 
• 97056-53-6 1,1,5,9-tetraethoxy-3,7-dimethyl-9-(4-methoxyphenyl)-2,6-nonadiene 
• 49571-76-8 methyl (Z)-3-(4-methoxyphenyl)-2-nitroacrylate 
• 49571-77-9 (E)-3-(4-Methoxy-phenyl)-2-nitro-acrylic acid methyl ester 
• 89553-28-6 (E)-5-ethoxy-5-(p-methyoxyphenyl)-2-pentenal 
• 92397-10-9 α,α-bis(7-hydroxy-4-isopropyltropon-2-yl)-4-methoxytoluene 

Relevant articles and documents

Conjugate addition of acetal-derived benzyl radicals generated from low-valent titanium-mediated CO bond cleavage

A new method for the generation of benzyl radicals from acetals via low-valent titanium-mediated homolytic CO bond cleavage is presented. The low cost and availability of the developed titanium reagent enable efficient access to α-alkoxy carbon radical species via the developed reaction.

Antimony(v) catalyzed acetalisation of aldehydes: An efficient, solvent-free, and recyclable process

A highly selective, solvent-free process for the acetalisation of aldehydes was achieved by the use of a readily accessible antimony(v) catalyst which we previously prepared in our lab as a tetraarylstibonium triflate salt ([1][OTf]). High yields of the acetals were achieved in the presence of stoichimetric amounts of either triethoxymethane or triethoxysilane. It was found that triethoxymethane reactions required longer time to reach completion when compared to triethoxysilane reactions which were completed upon mixing of the reagents. The products can be easily separated from the catalyst by distillation which enabled further use of [1][OTf] in additional calytic reactions (up to 6 cycles). Moreover, [1]+ also catalyzed the deprotection of the acetals into their corresponding aldehydes using only water as a solvent.

Development of a novel Br?nsted acid UiO-66 metal-organic framework catalyst by postsynthetic modification and its application in catalysis

A novel Br?nsted acid derived metal-organic framework (MOF) has been developed to serve as an efficient heterogeneous catalyst for the acetalization and Morita-Baylis-Hillman reaction. Aromatic sulfonic acid groups were successfully incorporated to the framework of UiO-66 by post-synthetic modifications using commercially available anhydridic reagents. The UiO-66-RArSO3H Br?nsted acid catalyst was fully characterized using SEM, PXRD, FTIR, TGA and N2 adsorption/desorption isotherms. Furthermore, efficient acetalization and Morita-Baylis-Hillman reactions were evaluated to demonstrate the high catalytic performance of the UiO-66-RArSO3H catalyst. The UiO-66-RArSO3H catalyst is compatible with a variety of substituted substrates and can be recycled five times without a compromise in the yield or selectivity.