24387-69-7 Usage
Description
Propyl Methanethiosulfonate (PMTS) is a clear, colorless oil that is known for its specific and rapid reaction with thiols to form mixed disulfides. This unique property allows PMTS to covalently bind to cysteine residues, making it a valuable tool in various applications.
Uses
Used in Pharmaceutical and Biomedical Research:
Propyl Methanethiosulfonate is used as a molecular probe for studying the function and structure of proteins, particularly those containing thiol groups. Its ability to form mixed disulfides with cysteine residues allows researchers to investigate protein-protein interactions, protein folding, and enzyme mechanisms.
Used in Neuroreceptor Studies:
In the field of neuroreceptor research, PMTS is used as a modifying agent to enhance receptor function. It covalently binds to cysteine residues introduced into specific sites in the glycine receptor and gamma-aminobutyric acid type A (GABA(A)) receptor subunits, leading to an irreversible enhancement of receptor function. This application is crucial for understanding the role of these receptors in the nervous system and their potential as therapeutic targets for various neurological disorders.
Used in Chemical Synthesis:
Propyl Methanethiosulfonate is also used as a reagent in chemical synthesis, particularly in the preparation of thiol-containing compounds and the formation of disulfide bonds in peptides and proteins. Its specificity for thiols makes it a valuable tool in the development of new drugs and bioactive molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 24387-69-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,3,8 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 24387-69:
(7*2)+(6*4)+(5*3)+(4*8)+(3*7)+(2*6)+(1*9)=127
127 % 10 = 7
So 24387-69-7 is a valid CAS Registry Number.
24387-69-7Relevant articles and documents
Marine bacteria from the Roseobacter clade produce sulfur volatiles via amino acid and dimethylsulfoniopropionate catabolism
Brock, Nelson L.,Menke, Markus,Klapschinski, Tim A.,Dickschat, Jeroen S.
supporting information, p. 4318 - 4323 (2014/06/23)
Dimethylsulfoniopropionate (DMSP) is a versatile sulfur source for the production of sulfur-containing secondary metabolites by marine bacteria from the Roseobacter clade. 34S-labelled DMSP and cysteine, and several DMSP derivatives with modified S-alkyl groups were synthesised and used in feeding experiments that gave insights into the biosynthesis of sulfur volatiles from these bacteria. the Partner Organisations 2014.
