24393-20-2

Basic information

• Product Name: 3-(1,3-dithian-2-yl)phenol
• Synonyms: 3-(1,3-dithian-2-yl)phenol;Phenol, 3-(1,3-dithian-2-yl)-
• CAS NO: 24393-20-2
• Molecular Formula: C₁₀H₁₂OS₂
• Molecular Weight: 212.3317
• Mol File: 24393-20-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 390.5°C at 760 mmHg
• Flash Point: 189.7°C
• Density: 1.263g/cm³
• Vapor Pressure: 1.18E-06mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 3-(1,3-dithian-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-dithian-2-yl)phenol(24393-20-2)
• EPA Substance Registry System: 3-(1,3-dithian-2-yl)phenol(24393-20-2)

Safety Data

• Hazardous Substances Data: 24393-20-2(Hazardous Substances Data)

Upstream product

• 109-80-8 1.3-propanedithiol 
• 100-83-4 meta-hydroxybenzaldehyde 
• 57529-04-1 2-chloro-1,3-dithiane 

Downstream Products

• 100-83-4 meta-hydroxybenzaldehyde 
• 220913-32-6 DB-67 
• 877438-46-5 2-(3-tert-butyldimethylsilanyloxyphenyl)-1,3-dithiane 

Relevant articles and documents

A 2 - substituted - 1, 3 - dithiane derivative of the preparation method

The invention provides a preparation method of a 2-substituted-1,3-dithiane derivative. The preparation method comprises the following steps: adding 1,3-dithiane (CAS:505-23-7) and 1,2-dichloroethane (DCE) or dichloromethane (DCM) into a reaction bottle, adding N-chlorosuccinimide (NCS) under ice-bath condition, and stirring for 0.5-1 h to prepare a 2-chloro-1,3-dithiane solution; and adding an aldehyde or ketone compound and a lewis acid catalyst into the above solution, and reacting to prepare the 2-substituted-1,3-dithiane derivative. By using the 1,3-dithiane solid and different types of aldehyde and keto-carbonyl compounds as raw material and using one or more of ferric trichloride, boron trifluoride diethyl etherate, methanesulfonic acid, aluminum trichloride, ferrous chloride and nickel chloride as catalysts, preparation of the 2-substituted-1,3-dithiane derivative is realized. The catalysts used in the invention are cheap and easily available, dosage of the catalysts is low and pollution of the catalysts is little. The solid raw materials used in the invention can avoid use of fetid toxic 1,3-dimercaptopropane with strong volatility, and the purpose of protecting an experimenter's body and reducing environmental pollution is realized. In addition, the preparation method has advantages of mild reaction condition, high yield, simple operation and the like.

Visible-light promoted dithioacetalization of aldehydes with thiols under aerobic and photocatalyst-free conditions

A novel photocatalyst-free visible-light-mediated dithioacetalization of aldehydes and thiols has been developed. This protocol is operationally simple, mild and atom-economical, which provides an environmental benign access to dithioacetals at room temperature under aerobic conditions.

Fe-catalyzed direct dithioacetalization of aldehydes with 2-chloro-1,3-dithiane

Present methods to synthesize 1,3-dithiane molecules require either harsh reaction conditions or highly specialized reagents. We have developed a catalytic dithioacetalization process that directly gains access to the corresponding 1,3-dithianes using aldehydes and 2-chloro-1,3-dithiane in a highly efficient manner. This methodology is beneficial due to mildness of the reaction conditions, and the dithioacetaliation process results in good to excellent yields by using 15 mol % of an iron catalyst.