24522-30-3 Usage
Description
2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide, also known as Leflunomide EP Impurity H, is an organic compound with a unique chemical structure that features a cyano group, a trifluoromethylphenyl group, and an acetamide group. 2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide has been identified for its potential applications in various fields due to its specific chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide is used as a synthetic intermediate for the preparation of aminothiophene carboxylates and carboxamides. These compounds serve as adenosine A1 receptor allosteric enhancers, which have potential applications in the treatment of various diseases and conditions, such as neurodegenerative disorders, cognitive impairment, and certain types of cancer.
Additionally, 2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide is utilized in the synthesis of (1,2,3-triazol-4-yl)benzenamines. These compounds are known to be inhibitors against vascular endothelial growth factor (VEGF) receptors 1 and 2. Inhibiting these receptors can be beneficial in the treatment of various diseases, particularly those related to angiogenesis, such as cancer, age-related macular degeneration, and diabetic retinopathy.
Check Digit Verification of cas no
The CAS Registry Mumber 24522-30-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,5,2 and 2 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 24522-30:
(7*2)+(6*4)+(5*5)+(4*2)+(3*2)+(2*3)+(1*0)=83
83 % 10 = 3
So 24522-30-3 is a valid CAS Registry Number.
24522-30-3Relevant articles and documents
NEW MALONITRILE DERIVATIVES
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Page/Page column 12, (2021/11/26)
The invention relates to a compound of formula (I) wherein R1-R2 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
Preparation process of continuous-flow teriflunomide
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Paragraph 0041; 0046-0048; 0053; 0058-0060; 0065; 0070-0072, (2021/11/21)
To the preparation process, cyanoacetic acid is used as a starting material, cyanoacetyl chloride is prepared by chlorination, and a tertamine intermediate is synthesized by cyanacetyl chloride and p-trifluoromethylaniline, and an intermediate is synthesized with acetyl chloride. The invention has high safety. The utility model has the advantages of low cost, low energy consumption and high production yield.
Nickel-promoted oxidative domino Csp3-H/N-H bond double-isocyanide insertion reaction to construct pyrrolin-2-ones
Wen, Li-Rong,Wang, Ning-Ning,Du, Wu-Bo,Ma, Qiang,Zhang, Lin-Bao,Li, Ming
supporting information, p. 2895 - 2900 (2021/04/14)
The first nickel-catalyzed oxidative domino Csp3-H/N-H double isocyanide insertion reaction of acetamides with isocyanides has been developed for the synthesis of pyrrolin-2-one derivatives. A wide range of acetamides bearing various functional groups are compatible with this reaction system by utilizing Ni(acac)2as a catalyst. In this transformation, isocyanide could serve as a C1 connector and insert into the inactive Csp3-H bond, representing an effective way to construct heterocycles.
