261901-57-9

Basic information

• Product Name: SB269970 HCl
• Synonyms: (r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride;SB 269970A, (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride;SB-269970A;(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride;(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine monohydrochloride;Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1);SB269970 hydrochloride, >=98%
• CAS NO: 261901-57-9
• Molecular Formula: C18H28N2O3SHCl
• Molecular Weight: 0
• Product Categories: Inhibitors
• Mol File: 261901-57-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble10mg/mL, clear (warmed to 60 °C)
• CAS DataBase Reference: SB269970 HCl(CAS DataBase Reference)
• NIST Chemistry Reference: SB269970 HCl(261901-57-9)
• EPA Substance Registry System: SB269970 HCl(261901-57-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 261901-57-9(Hazardous Substances Data)

Usage

Description

SB269970 HCl, also known as SB-269970, is a potent and selective 5-HT7 receptor antagonist. It is an analogue of SB-258719 and demonstrates high potency both in vivo and in vitro. SB269970 HCl is characterized by its ability to induce functional desensitization of the 5-HT7 receptor system, which may contribute to its rapid antidepressant-like effects in animal models. It exhibits high selectivity for the 5-HT7 receptor, with at least 100-fold selectivity over other 5-HT receptor subtypes except the human 5-HT5A receptor.

Uses

Used in Pharmaceutical Research:
SB269970 HCl is used as a research tool for studying the role of the 5-HT7 receptor in various neurobehavioral effects. Its high selectivity and potency make it a valuable compound for investigating the mechanisms underlying conditions such as schizophrenia, depression, and other cognitive deficits.
Used in Antidepressant Drug Development:
SB269970 HCl is used as a lead compound in the development of new antidepressant medications. Its rapid antidepressant-like effects in animal models suggest that it may be a promising candidate for the development of novel treatments for depression.
Used in Schizophrenia Research:
SB269970 HCl is used as a selective 5-HT7 receptor antagonist in the study of schizophrenia-like cognitive deficits. Its ability to target the 5-HT7 receptor may provide insights into the underlying causes of cognitive impairments associated with schizophrenia and contribute to the development of more effective treatments.
Used in Neuropharmacology:
SB269970 HCl is used as a pharmacological agent in the field of neuropharmacology to explore the interactions between serotonin and its various receptor subtypes. This can help researchers better understand the complex roles of serotonin in the central nervous system and develop more targeted therapies for a range of neurological and psychiatric disorders.

Biochem/physiol Actions

Primary Target5-HT

references

[1] hagan j j, price g w, jeffrey p, et al. characterization of sb-269970-a, a selective 5-ht7 receptor antagonist. british journal of pharmacology, 2000, 130(3): 539-548.

Upstream product

• 162711-45-7 3-benzyloxybenzenesulfonyl chloride 
• 201039-15-8 (R)-2-[2-(4-methyl-piperidin-1-yl)ethyl]pyrrolidine 

Relevant articles and documents

Efficient Arndt-Eistert synthesis of selective 5-HT7 receptor antagonist SB-269970

This contribution describes a novel Arndt-Eistert approach for the efficient synthesis of the potent and selective 5-HT7-antagonist, (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970), from D-proline. The synthesis was ca