2621-79-6Relevant articles and documents
PARG INHIBITORY COMPOUNDS
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Paragraph 00186; 00187, (2016/07/05)
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
NOVEL SYNTHESES OF ARYLCARBAMIC ESTERS FROM CARBON DIOXIDE AND AROMATIC AMINE VIA A ZINC CARBAMATE.
Yoshida,Ishii,Kawato,Yamashita,Yano,Inoue
, p. 2913 - 2916 (2007/10/02)
Arylcarbamic esters were synthesized directly from carbon dioxide and an aromatic amine via a zinc carbamate. The alkylation of the reaction mixture of carbon dioxide, an aromatic amine, and diethylzinc with dialkyl sulfate formed alkyl arylcarbamate in a high yield. Also, 2-hydroxycyclohexyl diphenylcarbamate was obtained selectively in a good yield by the reaction of carbon dioxide, epoxycyclohexane, and ethylzinc diphenylamide. Other arylcarbamates of 1,2-cyclohexanediol were obtained by the reactions of carbon dioxide, an aromatic amine, diethylzinc, and epoxycyclohexane.
Process for the production of blocked compounds optionally containing free hydroxyl groups and their use for the production of polyurethanes
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, (2008/06/13)
The present invention relates to a process for the production of compounds containing reversibly blocked and, optionally, free alcoholic hydroxyl groups, characterized in that organic compounds containing at least one alcoholic hydroxyl group, but otherwise being inert under the reaction conditions are reacted at 0° to 140° C. with N,N'-disubstituted 5-acylimino-imidazolidine diones. The present invention also relates to the use of these compounds for the production of polyurethanes.