26437-49-0Relevant articles and documents
Efficient One-Pot Synthesis of Mono- and Bis[di(2-pyridyl)phosphine Oxides] from Tris(2-pyridyl)phosphine
Malysheva, Svetlana F.,Gusarova, Nina K.,Belogorlova, Nataliya A.,Sutyrina, Anastasiya O.,Litvintsev, Yuriy I.,Albanov, Alexander I.,Sterkhova, Irina V.,Artem'ev, Alexander V.
, p. 2451 - 2454 (2016/10/24)
An efficient one-pot access to di(2-pyridyl)phosphine oxides Py2P(R)=O and bis[di(2-pyridyl)phosphine oxides] Py2P(O)-Z-P(O)Py has been developed based on the reaction of available tris(2-pyridyl)phosphine with various organic halides, followed by treatment of the resulting phosphonium salts with alkali in situ. The isolated yields of the phosphine oxides were in the range 40-96%.
Reaction of Tri(2-pyridyl)phosphine with Electron-Deficient Alkynes in Water: Stereoselective Synthesis of Functionalized Pyridylvinylphosphine Oxides
Arbuzova, Svetlana N.,Gusarova, Nina K.,Glotova, Tatyana E.,Ushakov, Igor A.,Verkhoturova, Svetlana I.,Korocheva, Anastasiya O.,Trofimov, Boris A.
, p. 639 - 643 (2015/10/05)
The reaction of tri(2-pyridyl)phosphine with electron-deficient alkynes in water proceeds under mild conditions (40-45 C, without catalyst, 4-5 h) with liberation of pyridine to give (E)-pyridylvinylphosphine oxides in 45-56 % yields, the only exception being the reaction with cyanophenylacetylene, which affords the corresponding vinylphosphine oxide of Z-configuration in 40 % yield. The reaction is likely triggered by the zwitterion, the adduct of tri(2-pyridyl)phosphine to the electrophilic acetylenes, the carbanionic center of which is then neutralized by a proton from water. The intermediate phosphonium hydroxide finally decomposes to the product.
Expedient one-pot organometallics-free synthesis of tris(2-pyridyl) phosphine from 2-bromopyridine and elemental phosphorus
Trofimov, Boris A.,Artem'Ev, Alexander V.,Malysheva, Svetlana F.,Gusarova, Nina K.,Belogorlova, Nataliya A.,Korocheva, Anastasiya O.,Gatilov, Yuriy V.,Mamatyuk, Victor I.
supporting information; experimental part, p. 2424 - 2427 (2012/06/01)
2-Bromopyridine reacts with elemental phosphorus (red or white) in a superbasic KOH/DMSO(H2O) suspension at 100 °C (for red phosphorus) and 75 °C (for white phosphorus) over 3 h to afford tris(2-pyridyl)phosphine in a 62% yield (from red phosphorus) and a 50% yield (from white phosphorus). Under microwave assistance, the reaction with red phosphorus takes just 20 min to produce tris(2-pyridyl)phosphine in 53% yield. A hitherto unknown complex, [Pd(PPy3)2Cl 2]·CH2Cl2, synthesized from tris(2-pyridyl)phosphine and PdCl2, has the cis-configuration; this is unusual for bis(phosphino)palladium dichloride complexes.
