2669-15-0

Basic information

• Product Name: 1,1'-(p-phenylenedicarbonyl)bis[hexahydro-2H-azepin-2-one]
• Synonyms: 1,1'-(p-phenylenedicarbonyl)bis[hexahydro-2H-azepin-2-one];1,1'-(1,4-Phenylenebiscarbonyl)bis(azacycloheptane-2-one);1,1'-(1,4-Phenylenedicarbonyl)bis(1,3,4,5,6,7-hexahydro-2H-azepin-2-one);1,1'-(1,4-Phenylenedicarbonyl)bis(hexahydro-1H-azepin-2-one)
• CAS NO: 2669-15-0
• Molecular Formula: C₂₀H₂₄N₂O₄
• Molecular Weight: 356.41556
• EINECS: 220-209-2
• Mol File: 2669-15-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 191-193 °C(Solv: ethanol (64-17-5))
• Boiling Point: 591.2±46.0 °C(Predicted)
• Appearance: /
• Density: 1.237±0.06 g/cm3(Predicted)
• PKA: -2.41±0.20(Predicted)
• CAS DataBase Reference: 1,1'-(p-phenylenedicarbonyl)bis[hexahydro-2H-azepin-2-one](CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-(p-phenylenedicarbonyl)bis[hexahydro-2H-azepin-2-one](2669-15-0)
• EPA Substance Registry System: 1,1'-(p-phenylenedicarbonyl)bis[hexahydro-2H-azepin-2-one](2669-15-0)

Safety Data

• Hazardous Substances Data: 2669-15-0(Hazardous Substances Data)

Usage

General Description

1,1'-(p-phenylenedicarbonyl)bis[hexahydro-2H-azepin-2-one, also known as HATU, is a chemical compound used in peptide synthesis. It is a coupling reagent that helps to facilitate the formation of peptide bonds between amino acids. HATU is known for its high efficiency in peptide synthesis and is commonly used in solid-phase peptide synthesis. It is a white to off-white powder that is soluble in various organic solvents. HATU has found applications in the pharmaceutical and biotechnology industries, where it is used in the production of peptide-based drugs and research peptides. It is important to handle HATU with caution, as it can be harmful if ingested or inhaled, and can cause irritation to the skin and eyes.

Upstream product

• 105-60-2 caprolactam 
• 100-20-9 terephthaloyl chloride 

Downstream Products

• 102461-69-8 3,3'-dichloro-dodecahydro-1,1'-terephthaloyl-bis-azepin-2-one 
• 133725-71-0 N,N'-terephthaloyl-di-(6-aminoperoxycaproic acid) 
• 105-60-2 caprolactam 
• 15088-23-0 N,N'-dibutyl-tetrephthaldiamide 
• 18928-62-6 Terephthalic acid bis-N-(2-hydroxyethyl)amide 
• 42478-58-0 N,N'-Dioctyl-terephthalamide 
• 15088-30-9 1,4-phenylenebis(piperidin-1-ylmethanone) 

Relevant articles and documents

Process for the preparation of amidoperoxycarboxylic acids

Process for the preparation of amidoperoxycarboxylic acids, comprising the process steps: ring opening of the N-acyllactam to give the corresponding amidocarboxylic acid and, subsequently, oxidation of the resulting amidocarboxylic acid to the correspondi