26829-43-6

Basic information

• Product Name: 6-METHOXYISOQUINOLIN-1-OL
• Synonyms: 6-methoxy-2H-isoquinolin-1-one;6-Methoxyisoquinolin-1(2H);6-METHOXYISOQUINOLIN-1-OL;6-methoxyisoquinolin-1(2H)-one;6-Methoxy-1,2-dihydroisoquinolin-1-one
• CAS NO: 26829-43-6
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.186
• Mol File: 26829-43-6.mol
• Article Data: 32

Chemical Properties

• Melting Point: 180 °C
• Boiling Point: 438.478°C at 760 mmHg
• Flash Point: 218.984°C
• Appearance: /
• Density: 1.199g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.79±0.20(Predicted)
• CAS DataBase Reference: 6-METHOXYISOQUINOLIN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXYISOQUINOLIN-1-OL(26829-43-6)
• EPA Substance Registry System: 6-METHOXYISOQUINOLIN-1-OL(26829-43-6)

Safety Data

• Hazardous Substances Data: 26829-43-6(Hazardous Substances Data)

Usage

General Description

6-Methoxyisoquinolin-1-ol is a chemical compound with the molecular formula C10H9NO2. It is a derivative of isoquinoline and belongs to the class of organic compounds known as isoquinolinols. 6-METHOXYISOQUINOLIN-1-OL has one methoxy group (-O-CH3) attached to the 6-position of the isoquinoline ring, as well as a hydroxyl group (-OH) attached to the 1-position. 6-Methoxyisoquinolin-1-ol is a pale yellow solid, and its exact properties and uses are not widely noted in the literature. However, it may have potential applications in the field of organic synthesis or medicinal chemistry.

InChI:InChI=1/C10H9NO2/c1-13-8-2-3-9-7(6-8)4-5-11-10(9)12/h2-6H,1H3,(H,11,12)

Upstream product

• 6099-04-3 trans-3-methoxycinnamic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 872496-89-4 (E)-3-(3-methoxyphenyl)acryloyl azide 
• 591767-62-3 6-methoxyisoquinoline 2-oxide 
• 52986-70-6 6-methoxyisoquinoline 
• 6099-04-3 3-methoxycinnamic acid 
• 15854-56-5 3-methoxy-cinnamic acid methyl ester 
• 24186-48-9 1-((E)-2-Isocyanato-vinyl)-3-methoxy-benzene 
• 591-31-1 3-methoxy-benzaldehyde 
• 108-05-4 vinyl acetate 
• 1293990-75-6 N-tert-pentanoyloxy-p-methoxybenzamide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 56030-38-7 3-methoxycinnamoyl chloride 
• 13162-05-5 n-vinylformamide 

Downstream Products

• 132997-77-4 1-chloro-6-methoxyisoquinoline 
• 923359-38-0 SAR-407899 
• 923278-23-3 4-bromo-6-methoxyisoquinolin-1(2H)-one 
• 1409964-75-5 4-bromo-1-chloro-6-methoxyisoquinoline 
• 1613479-60-9 C₁₆H₁₁F₂NO₂ 
• 1042031-55-9 2-(4-methoxyphenyl)-1(2H)-6-methoxyisoquinolinone 
• 266690-48-6 1-amino-6-methoxy-isoquinoline 
• 1781486-94-9 4-bromo-6-methoxyisoquinoline 

Relevant articles and documents

Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization

A novel, facile, and expeditious two-step synthesis of 3,4-unsubstituted isoquinolin-1(2H)-ones from a Suzuki cross-coupling between 2-halobenzonitriles and commercially available vinyl boronates followed by platinum-catalyzed nitrile hydrolysis and cyclization is described.

Light-induced [2 + 2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides

Cyclobutanes are an important class of motifs present in a wide range of natural products and other biologically significant molecules. A photocatalytic [2 + 2] cycloaddition between pyridones or isoquinolones and ethenesulfonyl fluoride was achieved, providing a portal to a class of unique cyclobutane-fused pyridinyl sulfonyl fluorides with quaternary rigid rings (30 examples). Further applications of these novel sulfonyl fluoride molecules in SuFEx click chemistry were also accomplished, providing the corresponding sulfonates and sulphonamides with reasonable yields.

Divergent Synthesis of Isoquinolone and Isocoumarin Derivatives by the Annulation of Benzoic Acid with N-Vinyl Amide

A simple and efficient method for the synthesis of isoquinolone and isocoumarin derivatives is reported. The method for the first time provides a one-step divergent synthesis of important isoquinolone and isocoumarin skeletons from benzoic acid by switching the coupling partners. In addition, a reliable mechanism has been proposed on the basis of experimental investigations, including kinetic isotope effect experiments, 13C labeling experiments, time-tracking experiments, and competitive experiments, as well as DFT calculation studies.