27143-09-5Relevant articles and documents
Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents
Chen, Ye,Ding, Shi,Du, Siyuan,Hou, Yunlei,Li, Chunyan,Li, Zhen,Liu, Fang,Liu, Ju,Shen, Jiwei,Wang, Huan,Wei, Hao,Wu, Shuang
, (2022/01/26)
Two series of novel 4-phenoxypyridine derivatives containing imidazole-4-carboxamide and 4-methyl-5-oxo-4,5-dihydro-1,2,4-triazole-3-carboxamide moieties were synthesized and evaluated for their in vitro inhibitory activities against c-Met kinase and anti
Bis-heterocycles. Part I: Tetrahydro-5,5′- bi(1,2,4-triazin-6-ones)
Mohammad, Hanan H.,El-Abadelah, Mustafa M.,Sabri, Salim S.,Awwadi, Firas F.,Voelter, Wolfgang
, p. 965 - 974 (2018/11/23)
Selected sets of tetrahydro-5,5′-bi(1,2,4-triazines) (1-3) appended with acetyl, benzoyl, and ester moieties at C-3 position and N-1 (p-substituted)phenyl ring have been prepared and characterized by spectral (IR, NMR, MS) data and X-ray diffraction for c
Separation of PALMITIC acid from over used oil for production of heterogeneous organic derivatives of potential biological activities
Soliman, Hanaa M.,El-Shattory
, p. 591 - 600 (2019/01/30)
PALMITIC acid was extracted from Over-used cooking oil where oil was filtered off, then it was hydrolyzed with distilled water in high pressure reactor at 250°C and 2 MPa to produce glycerol and mixture of fatty acids. Fatty acids mixture was cooled at 7°C in order to precipitate all saturated fatty acids, which were then filtered off, Palmitic acid was extracted from this mixture by means of supercritical CO2 extractor at 35.0 MPa and 55°C, followed by its methylation and confirmation by GC mass. Then it was used as precursor for production of a different heterocyclic compounds which were then tested for their antimicrobial activities. Thus the long-chain methyl palmitate was interacted with hydrazine hydrate to produce the corresponding acid hydrazide (2), and then it was treated with phenyl isothiocyanate, furnished the corresponding thiosemicarbazide 4. The later was reacted with ethyl chloro(arylhydrazono) acetate 5a-b in dimethylformamide, in the presence of triethylamine, afforded thiadiazole derivatives 7a-b. A solution of thiosemicarbazide 4 in ethanol was interacted with the a-haloketones 9 in the presence of triethylamine, produced the parallel thiadiazine 12. The structure elucidation of all synthesized compounds is based on the elemental analysis and spectral data (IR, 1H NMR, 13C NMR and MS).