27410-43-1

Basic information

• Product Name: Benzothiazole, 2-(propylthio)- (7CI,8CI,9CI)
• Synonyms: Benzothiazole, 2-(propylthio)- (7CI,8CI,9CI)
• CAS NO: 27410-43-1
• Molecular Formula: C₁₀H₁₁NS₂
• Molecular Weight: 209.33104
• Product Categories: BENZOTHIAZOLE
• Mol File: 27410-43-1.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzothiazole, 2-(propylthio)- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 2-(propylthio)- (7CI,8CI,9CI)(27410-43-1)
• EPA Substance Registry System: Benzothiazole, 2-(propylthio)- (7CI,8CI,9CI)(27410-43-1)

Safety Data

• Hazardous Substances Data: 27410-43-1(Hazardous Substances Data)

Upstream product

• 149-30-4 2-thioxo-3H-1,3-benzothiazole 
• 106-94-5 propyl bromide 
• 615-22-5 2-methylmercaptobenzothiazole 
• 75-03-6 ethyl iodide 
• 35590-17-1 propyl benzenecarboximidoate 
• 95-16-9 1,3-Benzothiazole 
• 6363-00-4 sodium n-propyl thiosulfate 
• 137-07-5 2-amino-benzenethiol 
• 872837-89-3 C₁₀H₂₂N₂O 
• 107-03-9 1-thiopropane 
• 107-08-4 1-iodo-propane 
• 149-30-4 2-Mercaptobenzothiazole 
• 75-15-0 carbon disulfide 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 27410-48-6 3-propylbenzothiazole-2-thione 
• 95793-43-4 2,2'-dithiodi-aniline 

Relevant articles and documents

Ag-Cu copromoted direct C2-H bond thiolation of azoles with Bunte salts as sulfur sources

A direct C2-H thiolation of azoles with Bunte salts was achieved under the combined action of copper and silver salts. This protocol could furnish various substituted 2-thioazoles in moderate to good yields. This method has a broad substrate scope and shows good functional group tolerance.

Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

Since its discovery 22 years ago, the bacterial cell-to-cell communication system, termed quorum sensing (QS), has shown potential as antipathogenic target. Previous studies reported that ajoene from garlic inhibits QS in opportunistic human pathogen Pseudomonas aeruginosa. In this study, screening of an in-house compound library revealed two sulfur-containing compounds which possess structural resemblance with ajoene and inhibit QS in bioreporter assay. Following a quantitative structure-activity relationship (SAR) study, 25 disulfide bond-containing analogues were synthesized and tested for QS inhibition activities. SAR study indicated that the allyl group could be replaced with other substituents, with the most active being benzothiazole derivative (IC50 = 0.56 μM). The compounds were able to reduce QS-regulated virulence factors (elastase, rhamnolipid, and pyocyanin) and successfully inhibit P. aeruginosa infection in murine model of implant-associated infection. Altogether, the QS inhibition activity of the synthesized compounds is encouraging for further exploration of novel analogues in antimicrobial drug development.

A novel synthesis of 2-alkylthiobenzothiazoles and 2-alkylthiobenzoxazoles

3H-Benzothiazole-2-thione and 3H-benzoxazole-2-thione were selectively S-alkylated by use of O-alkylisoureas as the alkylating reagents. The reactions could be performed under mild reaction conditions in short reaction times, and high yields were obtained using O-primary-alkylisoureas, whereas low yields were obtained with sec-and tert-alkylisoureas.