27548-93-2Relevant articles and documents
Synthesis, utility, and x-ray crystal structure of novel complexes of baccatin III with imidazole and 2-propanol
Gibson, Frank S.,Wei, Jianmei,Vemishetti, Purushotham,Gao, Qi,Dillon, John L.
, p. 3269 - 3271 (2000)
(matrix presented) Baccatin III forms crystalline complexes 4 and 5 with imidazole and 2-propanol, respectively. These compounds are useful in the purification of baccatin III from mixtures of taxanes derived from plant-cell fermentation.
Selective protection of the C(7) and C(10) hydroxyl groups in 10- deacetyl baccatin III
Holton, Robert A.,Zhang, Zhuming,Clarke, Paul A.,Nadizadeh, Hossain,Procter, D. John
, p. 2883 - 2886 (1998)
New protocols for the selective protection of the C(7) and C(10) hydroxyl groups of 10-deacetyl baccatin III are described, leading to more efficient semisyntheses of taxol and taxol analogs. The C(10) hydroxyl group of 10-DAB can be highly selectively acylated or silylated, and subsequent selective protection of the C(7) hydroxyl group then becomes straightforward.
Fluorinated taxane compound, preparation method therefor and application of fluorinated taxane compound
-
Paragraph 0048; 0085; 0093-0095, (2019/08/30)
The invention discloses a fluorinated taxane compound, a preparation method therefor and an application of the fluorinated taxane compound. The compound has a structural general formula represented bya formula I. Proven by pharmacological experiments, compared with paclitaxel, a series of fluorinated taxane derivatives synthesized by the method have cytotoxicity superior to that of the paclitaxelto a multidrug-resistant human mammary cancer cell line MCF-7/Adr and an ovarian cancer cell line NCI/Adr and represent cytotoxicity superior to that of the paclitaxel to a colon cancer cell line HCT-116 with overexpressed neoplasm stem cells.
Antagonizing NOD2 Signaling with Conjugates of Paclitaxel and Muramyl Dipeptide Derivatives Sensitizes Paclitaxel Therapy and Significantly Prevents Tumor Metastasis
Dong, Yi,Wang, Suhua,Wang, Chunting,Li, Zihua,Ma, Yao,Liu, Gang
supporting information, p. 1219 - 1224 (2017/02/19)
A noncleavable paclitaxel (PTX) and N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) derivative conjugate, 22 (DY-16-43), and its analogues were prepared and characterized as antagonists of NOD2 signaling. This conjugate enhanced the antitumor and antimetastatic efficacy of PTX in Lewis lung carcinoma (LLC) tumor-bearing mice. This work first describes a molecular strategy that enables the sensitization of a chemotherapeutic response via antagonizing NOD2 inflammatory signaling and suggests NOD2 antagonist as potential adjunct in treating non-small-cell lung cancer (NSCLC).