28123-72-0Relevant articles and documents
4-(Furan-2-yl)phenyl-containing polydithienylpyrroles as promising electrodes for high contrast and coloration efficiency electrochromic devices
Wang, Wen-Hsin,Chang, Jui-Cheng,Wu, Tzi-Yi
, p. 23 - 32 (2019)
A 4-(furan-2-yl)phenyl-containing conjugated dithienylpyrrole (FPT) was prepared using a Paal-Knorr reaction and its homologous homopolymer (PFPT) and copolymers (P(FPT-co-DTC) and P(FPT-co-DTP)) were electrosynthesized. Spectroelectrochemical investigations displayed that PFPT film was saffron yellow (0 V) in a reduced state, yellowish-gray (1.0 V), light purple (1.2 V), and bluish-purple (1.4 V) in an oxidized state. P(FPT-co-DTC) film was green, grayish-green, grayish-blue, and bluish-purple from reduced to oxidized states. Electrochromic switching studies revealed the transmittance change (ΔT) of PFPT, P(FPT-co-DTC), and P(FPT-co-DTP) films were 22.7%, 44.8%, and 50.7% at 1320 nm, 906 nm, and 1212 nm, respectively, and the coloration efficiency (η) of PFPT, P(FPT-co-DTC), and P(FPT-co-DTP) films were estimated to be 181.8 cm2 C?1, 229.0 cm2 C?1, and 232.4 cm2 C?1 at 1320 nm, 906 nm, and 1212 nm, respectively. A P(FPT-co-DTP)/PProDOT-Et2 ECD revealed a high ΔT (38.6% at 612 nm) and rapid switching time, whereas a PFPT/PProDOT-Et2 ECD attained a high ΔT (33.3% at 590 nm), a high η (533.5 cm2 C?1 at 590 nm) and long-term reversible redox behaviors.
Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities
Oh, Sangmi,Kwon, Do Yoon,Choi, Inhee,Kim, Young Mi,Lee, Ji Young,Ryu, Jiyoung,Jeong, Hangyeol,Kim, Myung Jin,Song, Rita
, p. 563 - 571 (2021/05/06)
This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.
Carbazole based Electron Donor Acceptor (EDA) catalysis for the synthesis of biaryl and aryl-heteroaryl compounds
Annes, Sesuraj Babiola,Ramesh, Subburethinam,Saravanan, Subramanian,Saritha, Rajendhiran
supporting information, p. 2510 - 2515 (2020/04/15)
A highly regioselective, carbazole based Electron Donor Acceptor (EDA) catalyzed synthesis of biaryl and aryl-heteroaryl compounds is described. Various indole and carbazole derivatives were screened for the Homolytic Aromatic Substitution (HAS) reaction. Tetrahydrocarbazole (THC) was very efficient for the HAS transformation and proceeded via a complex formation between diazonium salt and electron rich tetrahydrocarbazole. The UV-Vis spectroscopy technique has been used to confirm the complex formation. The in situ generated EDA complex even in a catalytic amount is found to be efficient for the Single Electron Transfer (SET) process without any photoactivation. Biaryl compounds, 2-phenylfuran, 2-phenylthiophene, and 2-phenylpyrrole and bioactive compounds such as dantrolene and canagliflozin have been synthesized in moderate to excellent yields.
