28353-03-9

Basic information

• Product Name: 6-OXO-6-PHENYLHEXANENITRILE
• Synonyms: 6-OXO-6-PHENYLHEXANENITRILE
• CAS NO: 28353-03-9
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.24
• Mol File: 28353-03-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 360.8°C at 760 mmHg
• Flash Point: 172°C
• Appearance: /
• Density: 1.038g/cm³
• Vapor Pressure: 2.16E-05mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 6-OXO-6-PHENYLHEXANENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-OXO-6-PHENYLHEXANENITRILE(28353-03-9)
• EPA Substance Registry System: 6-OXO-6-PHENYLHEXANENITRILE(28353-03-9)

Safety Data

• Hazardous Substances Data: 28353-03-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H13NO/c13-10-6-2-5-9-12(14)11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9H2

Upstream product

• 771-98-2 1-Phenylcyclohexene 
• 4144-62-1 5-benzoylvaleric acid 
• 111-69-3 hexanedinitrile 
• 98-80-6 phenylboronic acid 
• 20614-61-3 cyclohexyl-1-phenyl-1-hydroperoxide 
• 827-52-1 1-phenyl-1-cyclohexane 
• 7677-24-9 trimethylsilyl cyanide 
• 1624363-23-0 3-azido-2-methylbut-3-en-2-ol 
• 108-94-1 cyclohexanone 
• 108-86-1 bromobenzene 
• 100-42-5 styrene 
• 22591-17-9 2-phenylcyclohexanone oxime 
• 1444-65-1 (RS)-2-phenylcyclohexanone 
• 13735-81-4 1-styrenyloxytrimethylsilane 

Downstream Products

• 4829-02-1 (S)-(+)-2-hydroxy-2-phenylcyclohexanone 
• 4829-02-1 2-hydroxy-2-phenylcyclohexanone 

Relevant articles and documents

The Formation of C-C or C-N Bonds via the Copper-Catalyzed Coupling of Alkylsilyl Peroxides and Organosilicon Compounds: A Route to Perfluoroalkylation

The copper-catalyzed selective cleavage of alkylsilyl peroxides and the subsequent formation of carbon-carbon or carbon-nitrogen bonds with organosilicon compounds are described. The reaction proceeds under mild conditions and exhibits a broad substrate scope with respect to both cyclic and acyclic alkylsilyl peroxides in combination with carbon and nitrogen sources. In particular, this approach enables the facile radical perfluoroalkylation using commercially available perfluoroalkyltrimethylsilanes. Our mechanistic studies suggest that the reaction should proceed via a free-radical process.

In-situ-generation of alkylsilyl peroxides from alkyl hydroperoxides and their subsequent copper-catalyzed functionalization with organosilicon compounds

Alkylsilyl peroxides were generated in situ from the corresponding alkyl hydroperoxides using organosilicon compounds of the type Me3SiX (X = CN, N3, and halogens) and an amine base. Subsequent in situ copper-catalyzed homolytic cleavage of the alkylsilyl peroxides afforded alkyl radicals, which were then trapped with X (X = CN, N3, and halogens) to furnish products with new carbon-carbon, carbon-nitrogen, or carbon-halogen bonds in good to high yields.

Visible-light-promoted site-specific and diverse functionalization of a c(sp3)-c(sp3) bond adjacent to an arene

We report here a strategy for inert C-C bond functionalization. Site-specific cleavage and functionalization of a saturated C(sp3)-C(sp3) bond via a visible-light-induced radical process have been achieved. The general features of this reaction are as follows. (1) Both linear and cyclic C(sp3)-C(sp3) bonds with a vicinal arene can be specifically functionalized. (2) One carbon is converted into a ketone, and another can be tunably converted into nitrile, peroxide, or halide. (3) The typical conditions include 1.0 mol % of Ru(bpy)3Cl2, 1.0 or 5.0 equiv of Zhdankin reagent, white CFL (24 W), open flask, and room temperature. These reactions offer powerful tools to modify carbon skeletons that are intractable by conventional methods. Good selectivity and functional group tolerance, together with mild and open air conditions, make these transformations valuable and attractive.