28565-98-2

Basic information

• Product Name: 2-[(PHENYLACETYL)AMINO]BENZOIC ACID
• Synonyms: Anthranilicacid, N-(phenylacetyl)- (6CI,8CI); Benzoic acid, 2-[(phenylacetyl)amino]-(9CI); N-(Phenylacetyl)anthranilic acid
• CAS NO: 28565-98-2
• Molecular Formula: C₁₅H₁₃NO₃
• Molecular Weight: 255.28
• Mol File: 28565-98-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 517.7°C at 760 mmHg
• Flash Point: 266.9°C
• Appearance: /
• Vapor Pressure: 1.52E-11mmHg at 25°C
• CAS DataBase Reference: 2-[(PHENYLACETYL)AMINO]BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(PHENYLACETYL)AMINO]BENZOIC ACID(28565-98-2)
• EPA Substance Registry System: 2-[(PHENYLACETYL)AMINO]BENZOIC ACID(28565-98-2)

Safety Data

• Hazardous Substances Data: 28565-98-2(Hazardous Substances Data)

Usage

General Description

2-[(Phenylacetyl)amino]benzoic acid, also known as fenoprofen, is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to treat pain and inflammation associated with conditions such as arthritis and menstrual cramps. It functions by inhibiting the production of prostaglandins, which are responsible for causing pain and inflammation. This chemical is classified as a propionic acid derivative and is available in various forms, including tablets and capsules. Fenoprofen is typically taken orally and is absorbed into the bloodstream, where it exerts its anti-inflammatory and analgesic effects. However, as with all NSAIDs, fenoprofen can have potentially serious side effects, such as gastrointestinal bleeding, kidney damage, and cardiovascular problems, and should be used with caution and under the guidance of a healthcare professional.

InChI:InChI=1/C15H13NO3/c17-14(10-11-6-2-1-3-7-11)16-13-9-5-4-8-12(13)15(18)19/h1-9H,10H2,(H,16,17)(H,18,19)/p-1

Upstream product

• 118-92-3 anthranilic acid 
• 103-80-0 phenylacetyl chloride 
• 75541-63-8 methyl 2-(2-phenylacetamido)benzoate 
• 103-82-2 phenylacetic acid 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 58980-13-5 2-benzyl-4H-3,1-benzoxazine-4-one 
• 14933-29-0 3-phenyl-quinoline-2,4-diol 
• 91612-15-6 4-Diethylamino-3-phenyl-1H-benzo[b]azepine-2,5-dione 
• 19857-34-2 2-(phenylmethyl)-3-phenyl-4(3H)-quinazolinone 
• 201293-05-2 2-benzyl-3-(4-nitro-phenyl)-3H-quinazolin-4-one 
• 201293-02-9 2-(2-benzyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid 
• 19857-49-9 2-benzyl-3-(4-bromo-phenyl)-3H-quinazolin-4-one 
• 76244-49-0 4-(2-benzyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid 
• 91612-11-2 4-dimethylamino-2,5-dioxo-3-phenyl-1,2-dihydro-5H-1-benzazepine 

Relevant articles and documents

O-amino aromatic amide derivative as well as preparation method and application thereof

The invention discloses an o-amino aromatic amide derivative as well as a preparation method and application thereof. The o-amino aromatic amide derivative is a compound with a structural general formula I, II and III or a pharmaceutically acceptable salt

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.

Synthesis of some new glutamine linked 2,3-disubstituted quinazolinone derivatives as potent antimicrobial and antioxidant agents

A series of novel glutamine linked 2,3-disubstituted quinazolinone conjugates was synthesized from methyl anthranilate and different substituted acids and acid chlorides. The compounds 5a-l were prepared in good yields. All compounds were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria and for antifungal activity against Candida albicans and Aspergillus flavus using paper disk diffusion technique. The minimum inhibitory concentrations of the compounds were also determined by agar streak dilution method. The compound 5b was found to exhibit the most potent in vitro anti-microbial activity. When tested for their antioxidant activity, compounds 5i and 5l showed potent radical scavenging activity, while compound 5g had moderate effect against 2,2-diphenyl-1-picrylhydrazyl, hydroxyl, nitric oxide, and superoxide radical scavenging assays. These results suggest that, the three quinazolinone analogs (5g, 5i, and 5l) could be considered as useful templates for future development to obtain more potent antioxidant agents.