2866-82-2

Basic information

• Product Name: 4'-CHLOROBENZANILIDE, 98%
• Synonyms: Benzanilide,4'-chloro- (6CI,7CI,8CI); 4'-Chlorobenzanilide; N-(4-Chlorophenyl)benzamide;N-(p-Chlorophenyl)benzamide; N-Benzoyl-4-chloroaniline; NSC 83620
• CAS NO: 2866-82-2
• Molecular Formula: C₁₃H₁₀ClNO
• Molecular Weight: 231.68
• Mol File: 2866-82-2.mol
• Article Data: 206

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-CHLOROBENZANILIDE, 98%(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-CHLOROBENZANILIDE, 98%(2866-82-2)
• EPA Substance Registry System: 4'-CHLOROBENZANILIDE, 98%(2866-82-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 2866-82-2(Hazardous Substances Data)

Usage

General Description

4'-Chlorobenzanilide, with a purity of 98%, is a chemical compound used in various industrial applications. It is a white to off-white crystalline solid with a molecular formula of C13H10ClNO and a molecular weight of 229.68 g/mol. 4'-CHLOROBENZANILIDE, 98% is commonly used as an intermediate in the production of pharmaceuticals, dyes, and other organic compounds. It is also utilized as a precursor in the synthesis of other chemicals and as a starting material for organic reactions. 4'-Chlorobenzanilide is handled and stored under strict safety measures due to its potential hazards if mishandled. Overall, it is an important chemical with versatile uses in the chemical and pharmaceutical industries.

Upstream product

• 93-98-1 N-phenyl benzoyl amide 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 507-40-4 tert-butylhypochlorite 
• 574-66-3 Benzophenone oxime 
• 5014-47-1 N-chloro-N-phenylbenzamide 
• 2998-98-3 (Z)-(4-chlorophenyl)(phenyl)methanone oxime 
• 93-99-2 benzoic acid phenyl ester 
• 106-47-8 4-chloro-aniline 
• 98-88-4 benzoyl chloride 
• 19865-58-8 N-(4-chlorophenyl)-α-phenylnitrone 
• 67-56-1 methanol 
• 68236-17-9 C₃NS(O)(C₆H₅)2(C₆H₄Cl) 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 34918-76-8 N-(4-Chloro-phenyl)-benzimidoyl chloride 

Downstream Products

• 100-52-7 benzaldehyde 
• 1602-00-2 bis-(4-chloro-phenyl)-diazene 
• 1131896-99-5 C₂₁H₁₈ClN₃S₂ 
• 1131897-05-6 C₁₉H₁₅ClN₂S 
• 89-63-4 4-Chloro-2-nitroaniline 
• 79796-59-1 N-benzyl-N-(4-chlorophenyl)benzamide 
• 60011-73-6 N-benzo-p-chloranilid 
• 57761-72-5 1-(4-chloro-phenyl)-5-phenyl-1H-tetrazole 
• 425366-06-9 N-(4-chloro-phenyl)-benzimidic acid 4-cyano-phenyl ester 
• 425366-19-4 (4-chloro-phenyl)-phenylmethylidyne-ammonium 
• 666175-13-9 1-[(4-chlorophenylimino)phenylmethyl]-3-ethylthiourea 
• 666175-06-0 1-[(4-chlorophenylimino)phenylmethyl]-3-methylthiourea 
• 20800-28-6 N-(4-chloro-phenyl)-benzimidoyl isothiocyanate 

Relevant articles and documents

Approach toward the understanding of coupling mechanism for EDC reagent in solvent-free mechanosynthesis

A unique approach in mechanosynthesis, joining solid-state NMR spectroscopy, X-ray crystallography, and theoretical calculations, is employed for the first time to study the mechanism of the formation of the C- N amide bond using EDC?HCl as a coupling reagent. It has been proved that EDC?HCl, which in the crystal lattice exists exclusively in the cyclic form (X-ray data), easily undergoes transformation to a pseudocyclic stable intermediate in reaction with carboxylic acid forming a low-melt phase (differential scanning calorimetry, solid-state NMR). The obtained intermediate is reactive and can be further used for synthesis of amides in reaction with appropriate amines.

Photoinduced Annulation of N-Phenylbenzamides for the Synthesis of Phenanthridin-6(5H)-Ones

A general concise method for the synthesis phenanthridin-6(5H)-ones via photoinduced intramolecular annulation of N-phenylbenzamides was developed. Under argon atmosphere and room temperature, phenanthridin-6(5H)-ones were obtained via irradiation N-phenylbenzamides with a 280 nm UV lamp in the presence of methanesulfonic acid in toluene. The mechanism is illustrated and believed to proceed in the order of amides tautomerization, 6π-electric cyclization, [1,5]-H shift, amide-imidine tautomerization, keto-enol tautomerism and evolution hydrogen. (Figure presented.).

Fe-mediated synthesis of: N -aryl amides from nitroarenes and acyl chlorides

Amides are prevalent in nature and valuable functional compounds in agrochemical, pharmaceutical, and materials industries. In this work, we developed a selective and mild method for the synthesis of N-aryl amides. Starting from commercially available nitroarenes and acyl halides, N-aryl amides with good yields can be obtained in water. Especially in the process of transformation, Fe dust is the only reductant and additive, and the reaction can be easily performed on a large scale.

Visible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions

A metal-free heterogeneous photocatalysis has been developed for the synthesis of benzothiazoles via intramolecular C-H functionalization/C-S bond formation of thiobenzanilides by inexpensive graphitic carbon nitride (g-C3N4) under visible-light irradiation. This reaction provides access to a broad range of 2-substituted benzothiazoles in high yields under an air atmosphere at room temperature without addition of a strong base or organic oxidizing reagents. In addition, the catalyst was found to be stable and reusable after five reaction cycles.