28690-95-1

Basic information

• Product Name: 2-{4-nitrophenoxy}-4,6-dimethoxy-1,3,5-triazine
• Synonyms: 2-{4-nitrophenoxy}-4,6-dimethoxy-1,3,5-triazine
• CAS NO: 28690-95-1
• Molecular Formula: C₁₁H₁₀N₄O₅
• Molecular Weight: 278.2209
• Mol File: 28690-95-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 467.9±47.0 °C(Predicted)
• Appearance: /
• Density: 1.394±0.06 g/cm3(Predicted)
• PKA: 0.67±0.10(Predicted)
• CAS DataBase Reference: 2-{4-nitrophenoxy}-4,6-dimethoxy-1,3,5-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{4-nitrophenoxy}-4,6-dimethoxy-1,3,5-triazine(28690-95-1)
• EPA Substance Registry System: 2-{4-nitrophenoxy}-4,6-dimethoxy-1,3,5-triazine(28690-95-1)

Safety Data

• Hazardous Substances Data: 28690-95-1(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 3140-73-6 2-chloro-4,6-dimethoxy-1 ,3,5-triazine 
• 1124-31-8 potassium 4-nitrophenolate 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 33950-60-6 2-(4-chloro-phenoxy)-4,6-dimethoxy-[1,3,5]triazine 
• 33950-59-3 2-(4-methylphenoxy)-4,6-dimethoxy-1,3,5-triazine 
• 42030-75-1 1-(4-((4,6-dimethoxy-1,3,5-triazin-2-yl)oxy)phenyl)ethanone 
• 21002-15-3 2-phenyloxy-4,6-dimethoxy-1,3,5-triazine 
• 67-56-1 methanol 
• 1075-59-8 2-hydroxy-4,6-dimethoxy-1,3,5-triazine 
• 154719-88-7 2,4-Dimethoxy-6-(2,4,5-trichloro-phenoxy)-[1,3,5]triazine 
• 42030-76-2 4-((4,6-dimethoxy-1,3,5-triazin-2-yl)oxy)benzaldehyde 
• 28691-00-1 4-(4,6-dimethoxy-[1,3,5]triazin-2-yloxy)-aniline 
• 1190847-02-9 1H-indole-3-carboxylic acid [4-(4,6-dimethoxy-[1,3,5]triazine-2-yloxy)-phenyl]-amide 

Relevant articles and documents

FUSED-CYCLIC PYRAZOLONE FORMAMIDE COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Provided are a class of fused-cyclic pyrazolone formamide compounds and a preparation method therefor, a pharmaceutical composition and the use thereof. Specifically, provided is a compound having the structure as shown in formula (I) (with each group defined in the description). The compound can be used as an AXL inhibitor in the preparation of a pharmaceutical composition for treating tumors.

NOVEL INDOL CARBOXYLIC ACID BISPYRIDYL CARBOXAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD AND COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT2c receptors, act selectively on the 5-HT2c receptors, the derivatives rarely have adverse effects caused by other receptors. Because the derivatives effectively inhibit serotonin activity, they may be useful for treatment or prevention of obesity; urinary disorders such as urinary incontinence, premature ejaculation, erectile dysfunction, and prostatic hyperplasia; CNS disorders such as depression, anxiety, concern, panic disorder, epilepsy, obsessive-compulsive disorder, migraine, sleep disorder, withdrawal from drug abuse, Alzheimer's disease, and schizophrenia, associated with 5-HT2c receptors.

NOVEL INDOL CARBOXYLIC ACID BISPYRIDYL CARBOXAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD AND COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT2c receptors, act selectively on the 5-HT2c receptors, the derivatives rarely have adverse effects caused by other receptors. Because the derivatives effectively inhibit serotonin activity, they may be useful for treatment or prevention of obesity; urinary disorders such as urinary incontinence, premature ejaculation, erectile dysfunction, and prostatic hyperplasia; CNS disorders such as depression, anxiety, concern, panic disorder, epilepsy, obsessive-compulsive disorder, migraine, sleep disorder, withdrawal from drug abuse, Alzheimer's disease, and schizophrenia, associated with 5-HT2c receptors.